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Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death
NEDD8 is a ubiquitin‐like protein that activates cullin‐RING E3 ubiquitin ligases (CRLs). Here, we identify a novel role for NEDD8 in regulating the activity of poly(ADP‐ribose) polymerase 1 (PARP‐1) in response to oxidative stress. We show that treatment of cells with H(2)O(2) results in the accumu...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6418418/ https://ncbi.nlm.nih.gov/pubmed/30804002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100024 |
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