HapMap, pharmacogenomics, and the goal of personalized prescribing

Por O’Shaughnessy, Kevin M
Publicado em 2006

The genetics of essential hypertension

Por O'Shaughnessy, Kevin M
Publicado em 2001

Dissecting complex traits: recent advances in hypertension genomics

Por O'Shaughnessy, Kevin M
Publicado em 2009

Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K

Por Murthy, Meena, O’Shaughnessy, Kevin M.
Publicado no Physiol Rep (2019)

Salt handling and hypertension

Por O’Shaughnessy, Kevin M., Karet, Fiona E.
Publicado em 2004

ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3(Δ403‐459) mutation

Por Murthy, Meena, Kurz, Thimo, O'Shaughnessy, Kevin M.
Publicado no Physiol Rep (2016)

WNK signalling pathways in blood pressure regulation

Por Murthy, Meena, Kurz, Thimo, O’Shaughnessy, Kevin M.
Publicado no Cell Mol Life Sci (2016)

β1-Adrenoreceptor Polymorphisms and Blood Pressure: 49S Variant Increases Plasma Renin But Not Blood Pressure in Hypertensive Patients

Por Sandilands, Alastair J, O’Shaughnessy, Kevin M, , Yasmin
Publicado no Am J Hypertens (2019)

Renal and Brain Isoforms of WNK3 Have Opposite Effects on NCCT Expression

Por Glover, Mark, Zuber, Annie Mercier, O’Shaughnessy, Kevin M.
Publicado em 2009

A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190

Por Glover, Mark, Sweeney, Connor, Davis, Bill, O’Shaughnessy, Kevin M
Publicado em 2010

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure

Por Zhang, Jinwei, Siew, Keith, Macartney, Thomas, O'Shaughnessy, Kevin M., Alessi, Dario R.
Publicado no Hum Mol Genet (2015)

Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels

Por Hardege, Iris, Long, Lu, Al Maskari, Raya, Figg, Nicola, O’Shaughnessy, Kevin M.
Publicado no Clin Sci (Lond) (2018)

A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression

Por Al Maskari, Raya, Yasmin, Cleary, S, Figg, Nikki, Mehta, Sarju, Rassl, Doris, Wilkinson, Ian, O’Shaughnessy, Kevin M
Publicado no Eur J Hum Genet (2017)

Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success

Por Hiby, Susan E., Walker, James J., O'Shaughnessy, Kevin M., Redman, Christopher W.G., Carrington, Mary, Trowsdale, John, Moffett, Ashley
Publicado em 2004

Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells

Por Hardege, Iris, Xu, Shengxin, Gordon, Richard D., Thompson, Andrew J., Figg, Nichola, Stowasser, Michael, Murrell-Lagnado, Ruth, O'Shaughnessy, Kevin M.
Publicado no Mol Endocrinol (2015)

Role of the WNK-activated SPAK kinase in regulating blood pressure

Por Rafiqi, Fatema H, Zuber, Annie Mercier, Glover, Mark, Richardson, Ciaran, Fleming, Stewart, Jovanović, Sofija, Jovanović, Aleksandar, O'Shaughnessy, Kevin M, Alessi, Dario R
Publicado em 2010

A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?

Por Barber, Jennifer, McKeever, Tricia M, McDowell, Sarah E, Clayton, Jennifer A, Ferner, Robin E, Gordon, Richard D, Stowasser, Michael, O'Shaughnessy, Kevin M, Hall, Ian P, Glover, Mark
Publicado no Br J Clin Pharmacol (2015)

The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

Por Yasmin, Maskari, Raya Al, McEniery, Carmel M., Cleary, Sarah E., Li, Ye, Siew, Keith, Figg, Nichola L., Khir, Ashraf W., Cockcroft, John R., Wilkinson, Ian B., O’Shaughnessy, Kevin M.
Publicado no Sci Rep (2018)

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Por Schumacher, Frances-Rose, Siew, Keith, Zhang, Jinwei, Johnson, Clare, Wood, Nicola, Cleary, Sarah E, Al Maskari, Raya S, Ferryman, James T, Hardege, Iris, Figg, Nichola L, Enchev, Radoslav, Knebel, Axel, O’Shaughnessy, Kevin M, Kurz, Thimo
Publicado no EMBO Mol Med (2015)

Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome)

Por Glover, Mark, Ware, James S., Henry, Amanda, Wolley, Martin, Walsh, Roddy, Wain, Louise V., Xu, Shengxin, Van’t Hoff, William G., Tobin, Martin D., Hall, Ian P., Cook, Stuart, Gordon, Richard D., Stowasser, Michael, O’Shaughnessy, Kevin M.
Publicado em 2014