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Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
The STE20/SPS1-related proline/alanine-rich kinase (SPAK) controls blood pressure (BP) by phosphorylating and stimulating the Na-Cl (NCC) and Na-K-2Cl (NKCC2) co-transporters, which regulate salt reabsorption in the kidney. SPAK possesses a conserved carboxy-terminal (CCT) domain, which recognises R...
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| Publicado en: | Hum Mol Genet |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4512625/ https://ncbi.nlm.nih.gov/pubmed/25994507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv185 |
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