Role of the WNK-activated SPAK kinase in regulating blood pressure

Mutations within the with-no-K(Lys) (WNK) kinases cause Gordon's syndrome characterized by hypertension and hyperkalaemia. WNK kinases phosphorylate and activate the STE20/SPS1-related proline/alanine-rich kinase (SPAK) protein kinase, which phosphorylates and stimulates the key Na(+):Cl(−) cot...

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Detalhes bibliográficos
Main Authors: Rafiqi, Fatema H, Zuber, Annie Mercier, Glover, Mark, Richardson, Ciaran, Fleming, Stewart, Jovanović, Sofija, Jovanović, Aleksandar, O'Shaughnessy, Kevin M, Alessi, Dario R
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377268/
https://ncbi.nlm.nih.gov/pubmed/20091762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900058
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