The COP9 signalosome is vital for timely repair of DNA double-strand breaks

The DNA damage response is vigorously activated by DNA double-strand breaks (DSBs). The chief mobilizer of the DSB response is the ATM protein kinase. We discovered that the COP9 signalosome (CSN) is a crucial player in the DSB response and an ATM target. CSN is a protein complex that regulates the...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Meir, Michal, Galanty, Yaron, Kashani, Lior, Blank, Michael, Khosravi, Rami, Fernández-Ávila, María Jesús, Cruz-García, Andrés, Star, Ayelet, Shochot, Lea, Thomas, Yann, Garrett, Lisa J., Chamovitz, Daniel A., Bodine, David M., Kurz, Thimo, Huertas, Pablo, Ziv, Yael, Shiloh, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482063/
https://ncbi.nlm.nih.gov/pubmed/25855810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv270
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