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Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors

The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical collagen. Excessive signaling by DDR1 and DDR2 has been linked to the progression of various human diseases, including fibrosis, atherosclero...

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Detalhes bibliográficos
Main Authors: Canning, Peter, Tan, Li, Chu, Kiki, Lee, Sam W., Gray, Nathanael S., Bullock, Alex N.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058747/
https://ncbi.nlm.nih.gov/pubmed/24768818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.04.014
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