Top-down Proteomics: Ready for Prime Time?

door Chen, Bifan, Brown, Kyle A., Lin, Ziqing, Ge, Ying
Gepubliceerd in Anal Chem (2017)

Top-down Proteomics: Challenges, Innovations, and Applications in Basic and Clinical Research

door Brown, Kyle A., Melby, Jake A., Roberts, David S., Ge, Ying
Gepubliceerd in Expert Rev Proteomics (2020)

High-throughput Proteomics Enabled by a Photocleavable Surfactant

door Brown, Kyle A., Tucholski, Trisha, Eken, Christian, Knott, Samantha, Zhu, Yanlong, Jin, Song, Ge, Ying
Gepubliceerd in Angew Chem Int Ed Engl (2020)

Bridged Hybrid Monolithic Column Coupled to High-Resolution Mass Spectrometry for Top-down Proteomics

door Liang, Yu, Jin, Yutong, Wu, Zhijie, Tucholski, Trisha, Brown, Kyle A., Zhang, Lihua, Zhang, Yukui, Ge, Ying
Gepubliceerd in Anal Chem (2019)

Higher-order structural characterisation of native proteins and complexes by top-down mass spectrometry

door Zhou, Mowei, Lantz, Carter, Brown, Kyle A., Ge, Ying, Paša-Tolić, Ljiljana, Loo, Joseph A., Lermyte, Frederik
Gepubliceerd in Chem Sci (2020)

Top-down Proteomics of Endogenous Membrane Proteins Enabled by Cloud Point Enrichment and Multidimensional Liquid Chromatography-Mass Spectrometry

door Brown, Kyle A., Tucholski, Trisha, Alpert, Andrew J., Eken, Christian, Wesemann, Lucas, Kyrvasilis, Andreas, Jin, Song, Ge, Ying
Gepubliceerd in Anal Chem (2020)

Stable picodisc assemblies from saposin proteins and branched detergents

door Kurgan, Kathleen W., Chen, Bifan, Brown, Kyle A., Cobra, Paulo Falco, Ye, Xinyu, Ge, Ying, Gellman, Samuel H.
Gepubliceerd in Biochemistry (2021)

Novel Strategies to Address the Challenges in Top-Down Proteomics

door Melby, Jake A., Roberts, David S., Larson, Eli J., Brown, Kyle A., Bayne, Elizabeth F., Jin, Song, Ge, Ying
Gepubliceerd in J Am Soc Mass Spectrom (2021)

Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y(2) Receptor Ligand

door Song, Lijun, Risseeuw, Martijn D. P., Karalic, Izet, Barrett, Matthew O., Brown, Kyle A., Harden, T. Kendall, Van Calenbergh, Serge
Gepubliceerd in Molecules (2014)

A photo-cleavable surfactant for top-down proteomics

door Brown, Kyle A., Chen, Bifan, Guardado-Alvarez, Tania M., Lin, Ziqing, Hwang, Leekyoung, Ayaz-Guner, Serife, Jin, Song, Ge, Ying
Gepubliceerd in Nat Methods (2019)

Photocleavable Surfactant-Enabled Extracellular Matrix Proteomics

door Knott, Samantha J., Brown, Kyle A., Josyer, Harini, Carr, Austin, Inman, David, Jin, Song, Friedl, Andreas, Ponik, Suzanne, Ge, Ying
Gepubliceerd in Anal Chem (2020)

4-Alkyloxyimino Derivatives of Uridine-5′-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y(2), P2Y(4), and P2Y(6) Receptors

door Jayasekara, P. Suresh, Barrett, Matthew O., Ball, Christopher B., Brown, Kyle A., Hammes, Eva, Balasubramanian, Ramachandran, Harden, T. Kendall, Jacobson, Kenneth A.
Gepubliceerd in 2014

Design, Synthesis and Pharmacological Characterization of a Fluorescent Agonist of the P2Y(14) Receptor

door Kiselev, Evgeny, Balasubramanian, Ramachandran, Uliassi, Elisa, Brown, Kyle A., Trujillo, Kevin, Katritch, Vsevolod, Hammes, Eva, Stevens, Raymond C., Harden, T. Kendall, Jacobson, Kenneth A.
Gepubliceerd in Bioorg Med Chem Lett (2015)

4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y(6) receptor()

door Jayasekara, P. Suresh, Barrett, Matthew O., Ball, Christopher B., Brown, Kyle A., Kozma, Eszter, Costanzi, Stefano, Squarcialupi, Lucia, Balasubramanian, Ramachandran, Maruoka, Hiroshi, Jacobson, Kenneth A.
Gepubliceerd in Medchemcomm (2013)

Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum

door Tiambeng, Timothy N., Roberts, David S., Brown, Kyle A., Zhu, Yanlong, Chen, Bifan, Wu, Zhijie, Mitchell, Stanford D., Guardado-Alvarez, Tania M., Jin, Song, Ge, Ying
Gepubliceerd in Nat Commun (2020)

Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y(14) Receptor Antagonists

door Junker, Anna, Balasubramanian, Ramachandran, Ciancetta, Antonella, Uliassi, Elisa, Kiselev, Evgeny, Martiriggiano, Chiara, Trujillo, Kevin, Mtchedlidze, Giorgi, Birdwell, Leah, Brown, Kyle A., Harden, T. Kendall, Jacobson, Kenneth A.
Gepubliceerd in J Med Chem (2016)

Development of Dual PLD1/2 and PLD2 Selective Inhibitors From a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 that Decrease Invasive Migration in U87-MG Gl...

door O’Reilly, Matthew C., Scott, Sarah A., Brown, Kyle A., Oguin, Thomas H., Thomas, Paul G., Daniels, J. Scott, Morrison, Ryan, Brown, H. Alex, Lindsley, Craig W.
Gepubliceerd in 2013

Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y(14) Receptor Antagonist Molecular Probes

door Kiselev, Evgeny, Barrett, Matthew O., Katritch, Vsevolod, Paoletta, Silvia, Weitzer, Clarissa D., Brown, Kyle A., Hammes, Eva, Yin, Andrew L., Zhao, Qiang, Stevens, Raymond C., Harden, T. Kendall, Jacobson, Kenneth A.
Gepubliceerd in ACS Chem Biol (2014)

Discovery of Desketoraloxifene Analogues as Inhibitors of Mammalian, Pseudomonas aeruginosa, and NAPE Phospholipase D Enzymes

door Scott, Sarah A., Spencer, Cierra T., O’Reilly, Matthew C., Brown, Kyle A., Lavieri, Robert R., Cho, Chul-Hee, Jung, Dai-Il, Larock, Richard C., Brown, H. Alex, Lindsley, Craig W.
Gepubliceerd in ACS Chem Biol (2014)