Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y(14) Receptor Antagonists

[Image: see text] UDP and UDP-glucose activate the P2Y(14) receptor (P2Y(14)R) to modulate processes related to inflammation, diabetes, and asthma. A computational pipeline suggested alternatives to naphthalene of a previously reported P2Y(14)R antagonist (3, PPTN) using docking and molecular dynami...

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Pubblicato in:J Med Chem
Autori principali: Junker, Anna, Balasubramanian, Ramachandran, Ciancetta, Antonella, Uliassi, Elisa, Kiselev, Evgeny, Martiriggiano, Chiara, Trujillo, Kevin, Mtchedlidze, Giorgi, Birdwell, Leah, Brown, Kyle A., Harden, T. Kendall, Jacobson, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947982/
https://ncbi.nlm.nih.gov/pubmed/27331270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00044
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