Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y(14) Receptor Antagonist Molecular Probes

[Image: see text] The P2Y(14) receptor (P2Y(14)R), one of eight P2Y G protein-coupled receptors (GPCR), is involved in inflammatory, endocrine, and hypoxic processes and is an attractive pharmaceutical target. The goal of this research is to develop high-affinity P2Y(14)R fluorescent probes based on...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Kiselev, Evgeny, Barrett, Matthew O., Katritch, Vsevolod, Paoletta, Silvia, Weitzer, Clarissa D., Brown, Kyle A., Hammes, Eva, Yin, Andrew L., Zhao, Qiang, Stevens, Raymond C., Harden, T. Kendall, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273980/
https://ncbi.nlm.nih.gov/pubmed/25299434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500614p
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