4-Alkyloxyimino Derivatives of Uridine-5′-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y(2), P2Y(4), and P2Y(6) Receptors

[Image: see text] Extended N(4)-(3-arylpropyl)oxy derivatives of uridine-5′-triphosphate were synthesized and potently stimulated phospholipase C stimulation in astrocytoma cells expressing G protein-coupled human (h) P2Y receptors (P2YRs) activated by UTP (P2Y(2/4)R) or UDP (P2Y(6)R). The potent P2...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Jayasekara, P. Suresh, Barrett, Matthew O., Ball, Christopher B., Brown, Kyle A., Hammes, Eva, Balasubramanian, Ramachandran, Harden, T. Kendall, Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018175/
https://ncbi.nlm.nih.gov/pubmed/24712832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500367e
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados