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A photo-cleavable surfactant for top-down proteomics
We report the identification of a photo-cleavable anionic surfactant, 4-hexylphenylazosulfonate (Azo) that can be rapidly degraded upon UV irradiation, for top-down proteomics. Azo can effectively solubilize proteins with performance comparable to SDS and is mass spectrometry (MS)-compatible. Import...
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| Publicado no: | Nat Methods |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6532422/ https://ncbi.nlm.nih.gov/pubmed/30988469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0391-1 |
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