Coupling functionalized cobalt ferrite nanoparticle enrichment with online LC/MS/MS for top-down phosphoproteomics

Phosphorylation plays pivotal roles in cellular processes and dysregulated phosphorylation is considered as an underlying mechanism in many human diseases. Top-down mass spectrometry (MS) analyzes intact proteins and provides a comprehensive analysis of protein phosphorylation. However, top-down MS-...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Chen, Bifan, Hwang, Leekyoung, Ochowicz, William, Lin, Ziqing, Guardado-Alvarez, Tania M., Cai, Wenxuan, Xiu, Lichen, Dani, Kunal, Colah, Cyrus, Jin, Song, Ge, Ying
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472028/
https://ncbi.nlm.nih.gov/pubmed/28660060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc05435h
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