Depleting tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC

par Madajewski, Brian, Boatman, Michael A., Chakrabarti, Gaurab, Boothman, David A., Bey, Erik A.
Publié dans Mol Cancer Res (2015)

β-Lapachone-containing PEG-PLA Polymer Micelles as Novel Nanotherapeutics against NQO1-Overexpressing Tumor Cells

par Blanco, Elvin, Bey, Erik A., Dong, Ying, Weinberg, Brent D., Sutton, Damon M., Boothman, David A., Gao, Jinming
Publié 2007

Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy

par Huang, Gang, Chen, Huabing, Dong, Ying, Luo, Xiuquan, Yu, Haijun, Moore, Zachary, Bey, Erik A., Boothman, David A., Gao, Jinming
Publié 2013

Hemoglobin-Based Oxygen Carrier Mitigates Transfusion-Mediated Pancreas Cancer Progression

par Lo, Karen K., Bey, Erik A., Patra, Biswantha, Benson, Douglas D., Boothman, David A., Silliman, Christopher C., Barnett, Carlton C.
Publié 2013

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

par Morales, Julio C., Li, Longshan, Fattah, Farjana J., Dong, Ying, Bey, Erik A., Patel, Malina, Gao, Jinming, Boothman, David A.
Publié dans Crit Rev Eukaryot Gene Expr (2014)

Dual PI3K/mTOR blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

par Konstantinidou, Georgia, Bey, Erik A., Rabellino, Andrea, Schuster, Katja, Maira, Michael S., Gazdar, Adi F., Amici, Augusto, Boothman, David A., Scaglioni, Pier Paolo
Publié 2009

Intratumoral Delivery of β-Lapachone via Polymer Implants for Prostate Cancer Therapy

par Dong, Ying, Chin, Shook-Fong, Blanco, Elvin, Bey, Erik A, Kabbani, Wareef, Xie, Xian-Jin, Bornmann, William G., Boothman, David A., Gao, Jinming
Publié 2009

Prostate cancer radiosensitization through PARP-1 hyperactivation

par Dong, Ying, Bey, Erik A., Li, Long-Shan, Kabbani, Wareef, Yan, Jingsheng, Xie, Xian-Jin, Hsieh, Jer-Tsong, Gao, Jinming, Boothman, David A.
Publié 2010

In vivo Off-Resonance Saturation Magnetic Resonance Imaging of α(v)β(3)-Targeted Superparamagnetic Nanoparticles

par Khemtong, Chalermchai, Kessinger, Chase W., Ren, Jimin, Bey, Erik A., Yang, Su-Geun, Guthi, Jagadeesh Setti, Boothman, David A., Sherry, A. Dean, Gao, Jinming
Publié 2009

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone

par Bey, Erik A., Bentle, Melissa S., Reinicke, Kathryn E., Dong, Ying, Yang, Chin-Rang, Girard, Luc, Minna, John D., Bornmann, William G., Gao, Jinming, Boothman, David A.
Publié 2007

NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers

par Motea, Edward A., Huang, Xiumei, Singh, Naveen, Kilgore, Jessica, Williams, Noelle, Xie, Xian-Jin, Gerber, David E., Beg, Muhammad Shaalan, Bey, Erik A., Boothman, David A.
Publié dans Clin Cancer Res (2019)

Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer

par Starcher, Colton L., Pay, S. Louise, Singh, Naveen, Yeh, I-Ju, Bhandare, Snehal B., Su, Xiaolin, Huang, Xiumei, Bey, Erik A., Motea, Edward A., Boothman, David A.
Publié dans Front Oncol (2020)

β-Lapachone Micellar Nanotherapeutics for Non-Small Cell Lung Cancer Therapy

par Blanco, Elvin, Bey, Erik A., Khemtong, Chalermchai, Yang, Su-Geun, Setti-Guthi, Jagadeesh, Chen, Huabing, Kessinger, Chase W., Carnevale, Kevin A., Bornmann, William G., Boothman, David A., Gao, Jinming
Publié 2010

Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of β-Lapachone for Pancreatic Cancer Therapy

par Li, Long Shan, Bey, Erik A., Dong, Ying, Meng, Jieru, Patra, Biswanath, Yan, Jingsheng, Xie, Xian-Jin, Brekken, Rolf A., Barnett, Carlton C., Bornmann, William G., Gao, Jinming, Boothman, David A.
Publié dans Clin Cancer Res (2011)

An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

par Huang, Xiumei, Dong, Ying, Bey, Erik A., Kilgore, Jessica A., Bair, Joseph S., Li, Long-Shan, Patel, Malina, Parkinson, Elizabeth I., Wang, Yiguang, Williams, Noelle S., Gao, Jinming, Hergenrother, Paul J., Boothman, David A.
Publié dans Cancer Res (2012)

Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers

par Bey, Erik A., Reinicke, Kathryn E., Srougi, Melissa C., Varnes, Marie, Anderson, Vernon, Pink, John J., Li, Long Shan, Patel, Malina, Cao, Lifen, Moore, Zachary, Rommel, Amy, Boatman, Michael, Lewis, Cheryl, Euhus, David M., Bornmann, William G., Buchsbaum, Donald J., Spitz, Douglas R., Gao, Jinming, Boothman, David A.
Publié 2013

Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers

par Cao, Lifen, Li, Long Shan, Spruell, Christopher, Xiao, Ling, Chakrabarti, Gaurab, Bey, Erik A., Reinicke, Kathryn E., Srougi, Melissa C., Moore, Zachary, Dong, Ying, Vo, Peggy, Kabbani, Wareef, Yang, Chin-Rang, Wang, Xiaoyu, Fattah, Farjana, Morales, Julio C., Motea, Edward A., Bornmann, William G., Yordy, John S., Boothman, David A.
Publié 2014

Y Chromosome LncRNA are involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells

par Brownmiller, Tayvia, Juric, Jamie A., Ivey, Abby D., Harvey, Brandon M., Westemeier, Emily S., Winters, Michael T., Stevens, Alyson M., Stanley, Alana N., Hayes, Karen E., Sprowls, Samuel A., Ammer, Amanda S. Gatesman, Walker, Mackenzee, Bey, Erik A., Wu, Xiaoliang, Lim, Zuan-Fu, Zhu, Lin, Wen, Sijin, Hu, Gangqing, Ma, Patrick C., Martinez, Ivan
Publié dans Cancer Res (2020)

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase (PARP) Inhibitors

par Huang, Xiumei, Motea, Edward A., Moore, Zachary R., Yao, Jun, Dong, Ying, Chakrabarti, Gaurab, Kilgore, Jessica A., Silvers, Molly A., Patidar, Praveen L., Cholka, Agnieszka, Fattah, Farjana, Cha, Yoonjeong, Anderson, Glenda G., Kusko, Rebecca, Peyton, Michael, Yan, Jingsheng, Xie, Xian-Jin, Sarode, Venetia, Williams, Noelle S., Minna, John D., Beg, Muhammad, Gerber, David E., Bey, Erik A., Boothman, David A.
Publié dans Cancer Cell (2016)