DNA Polymerases as Therapeutic Targets

Por Berdis, Anthony J.
Publicado em 2008

Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer

Por Berdis, Anthony J.
Publicado no Front Mol Biosci (2017)

Non-Natural Nucleotides as Probes for the Mechanism and Fidelity of DNA Polymerases

Por Lee, Irene, Berdis, Anthony J.
Publicado em 2009

A Novel Non-Natural Nucleoside that Influences P-glycoprotein Activity and Mediates Drug Resistance

Por Eng, Kevin T., Berdis, Anthony J.
Publicado em 2010

Simultaneous formation of functional leading and lagging strand holoenzyme complexes on a small, defined DNA substrate

Por Berdis, Anthony J., Benkovic, Stephen J.
Publicado em 1998

Terminal Deoxynucleotidyl Transferase: The Story of a Misguided DNA Polymerase

Por Motea, Edward A., Berdis, Anthony J.
Publicado em 2009

The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation

Por Berdis, Anthony J., Soumillion, Patrice, Benkovic, Stephen J.
Publicado em 1996

Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis

Por Motea, Edward A., Lee, Irene, Berdis, Anthony J.
Publicado em 2011

Development of a ‘clickable’ non-natural nucleotide to visualize the replication of non-instructional DNA lesions

Por Motea, Edward A., Lee, Irene, Berdis, Anthony J.
Publicado em 2012

A Non-Natural Nucleoside with Combined Therapeutic and Diagnostic Activities Against Leukemia

Por Motea, Edward A., Lee, Irene, Berdis, Anthony J.
Publicado em 2012

The Mechanism and Dynamics of Translesion DNA Synthesis Catalyzed by the Escherichia coli Klenow fragment

Por Sheriff, Asim, Motea, Edward, Lee, Irene, Berdis, Anthony J.
Publicado em 2008

Replication of a Universal Nucleobase Provides Unique Insight into the Role of Entropy During DNA Polymerization and Pyrophosphorolysis

Por Zhang, Xuemei, Motea, Edward, Lee, Irene, Berdis, Anthony J.
Publicado em 2010

Exploring the Roles of Nucleobase Desolvation and Shape Complementarity during the Misreplication of O(6)-Methylguanine

Por Chavarria, Delia, Ramos-Serrano, Andrea, Hirao, Ichiro, Berdis, Anthony J.
Publicado em 2011

A Metal-containing Nucleoside That Possesses Both Therapeutic and Diagnostic Activity against Cancer

Por Choi, Jung-Suk, Maity, Ayan, Gray, Thomas, Berdis, Anthony J.
Publicado no J Biol Chem (2015)

The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites

Por Krishnamurthy, Nirmala, Ngam, Caitlyn R., Berdis, Anthony J., Montano, Monica M.
Publicado em 2011

Gold-Containing Indoles as Anti-Cancer Agents that Potentiate the Cytotoxic Effects of Ionizing Radiation

Por Craig, Sandra, Gao, Lei, Lee, Irene, Gray, Thomas, Berdis, Anthony J.
Publicado em 2012

The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta

Por Choi, Jung-Suk, Dasari, Anvesh, Hu, Peter, Benkovic, Stephen J., Berdis, Anthony J.
Publicado no Nucleic Acids Res (2016)

A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNA

Por Berdis, Anthony J., Lee, Irene, Coward, James K., Stephens, Craig, Wright, Rachel, Shapiro, Lucy, Benkovic, Stephen J.
Publicado em 1998

Active-site directed chemical tools for profiling mitochondrial Lon protease

Por Fishovitz, Jennifer, Li, Min, Frase, Hilary, Hudak, Jason, Craig, Sandra, Ko, Kristin, Berdis, Anthony J., Suzuki, Carolyn K., Lee, Irene
Publicado em 2011

Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme

Por Misko, Tessianna A., Wijerathna, Sanath R., Radivoyevitch, Tomas, Berdis, Anthony J., Ahmad, Md. Faiz, Harris, Michael E., Dealwis, Chris G.
Publicado no FEBS Lett (2016)