Locking out viral replication

nork Begley, Darren W, Varani, Gabriele
Argitaratua 2009

Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping

nork Begley, Darren W., Zheng, Suxin, Varani, Gabriele
Argitaratua 2010

A small molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments

nork Davidson, Amy, Begley, Darren W., Lau, Carmen, Varani, Gabriele
Argitaratua 2011

Fragment Screening of Infectious Disease Targets in a Structural Genomics Environment

nork Begley, Darren W, Davies, Douglas R, Hartley, Robert, Edwards, Thomas E, Staker, Bart L, Van Voorhis, Wesley C, Myler, Peter J, Stewart, Lance J
Argitaratua izan da Methods Enzymol (2011)

Structural genomics of infectious disease drug targets: the SSGCID

nork Stacy, Robin, Begley, Darren W., Phan, Isabelle, Staker, Bart L., Van Voorhis, Wesley C., Varani, Gabriele, Buchko, Garry W., Stewart, Lance J., Myler, Peter J.
Argitaratua 2011

Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents

nork Goshu, Gashaw M., Ghose, Debarati, Bain, Joy M., Pierce, Phillip G., Begley, Darren W., Hewitt, Stephen N., Udell, Hannah S., Myler, Peter J., Meganathan, R, Hagen, Timothy J.
Argitaratua izan da Bioorg Med Chem Lett (2015)

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

nork Begley, Darren W., Davies, Douglas R., Hartley, Robert C., Hewitt, Stephen N., Rychel, Amanda L., Myler, Peter J., Van Voorhis, Wesley C., Staker, Bart L., Stewart, Lance J.
Argitaratua 2011

Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei

nork Begley, Darren W., Hartley, Robert C., Davies, Douglas R., Edwards, Thomas E., Leonard, Jess T., Abendroth, Jan, Burris, Courtney A., Bhandari, Janhavi, Myler, Peter J., Staker, Bart L., Stewart, Lance J.
Argitaratua 2011

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis

nork Begley, Darren W., Edwards, Thomas E., Raymond, Amy C., Smith, Eric R., Hartley, Robert C., Abendroth, Jan, Sankaran, Banumathi, Lorimer, Donald D., Myler, Peter J., Staker, Bart L., Stewart, Lance J.
Argitaratua 2011

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit

nork Armour, Brianna L., Barnes, Steve R., Moen, Spencer O., Smith, Eric, Raymond, Amy C., Fairman, James W., Stewart, Lance J., Staker, Bart L., Begley, Darren W., Edwards, Thomas E., Lorimer, Donald D.
Argitaratua 2013

The Protein Maker: an automated system for high-throughput parallel purification

nork Smith, Eric R., Begley, Darren W., Anderson, Vanessa, Raymond, Amy C., Haffner, Taryn E., Robinson, John I., Edwards, Thomas E., Duncan, Natalie, Gerdts, Cory J., Mixon, Mark B., Nollert, Peter, Staker, Bart L., Stewart, Lance J.
Argitaratua 2011

Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei

nork Zhang, Zheng, Jakkaraju, Sriram, Blain, Joy, Gogol, Kenneth, Zhao, Lei, Hartley, Robert C., Karlsson, Courtney A., Staker, Bart L., Stewart, Lance J., Myler, Peter J., Clare, Michael, Begley, Darren W., Horn, James R., Hagen, Timothy J
Argitaratua 2013

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors

nork Haft, Daniel H., Pierce, Phillip G., Mayclin, Stephen J., Sullivan, Amy, Gardberg, Anna S., Abendroth, Jan, Begley, Darren W., Phan, Isabelle Q., Staker, Bart L., Myler, Peter J., Marathias, Vasilios M., Lorimer, Donald D., Edwards, Thomas E.
Argitaratua izan da Sci Rep (2017)

Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1

nork Moen, Spencer O., Abendroth, Jan, Fairman, James W., Baydo, Ruth O., Bullen, Jameson, Kirkwood, Jennifer L., Barnes, Steve R., Raymond, Amy C., Begley, Darren W., Henkel, Greg, McCormack, Ken, Tam, Vincent C., Phan, Isabelle, Staker, Bart L., Stacy, Robin, Myler, Peter J., Lorimer, Don, Edwards, Thomas E.
Argitaratua 2014

A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial Immunophilins

nork Begley, Darren W., Fox, David, Jenner, Dominic, Juli, Christina, Pierce, Phillip G., Abendroth, Jan, Muruthi, Muigai, Safford, Kris, Anderson, Vanessa, Atkins, Kateri, Barnes, Steve R., Moen, Spencer O., Raymond, Amy C., Stacy, Robin, Myler, Peter J., Staker, Bart L., Harmer, Nicholas J., Norville, Isobel H., Holzgrabe, Ulrike, Sarkar-Tyson, Mitali, Edwards, Thomas E., Lorimer, Donald D.
Argitaratua 2014

Combining Functional and Structural Genomics to Sample the Essential Burkholderia Structome

nork Baugh, Loren, Gallagher, Larry A., Patrapuvich, Rapatbhorn, Clifton, Matthew C., Gardberg, Anna S., Edwards, Thomas E., Armour, Brianna, Begley, Darren W., Dieterich, Shellie H., Dranow, David M., Abendroth, Jan, Fairman, James W., Fox, David, Staker, Bart L., Phan, Isabelle, Gillespie, Angela, Choi, Ryan, Nakazawa-Hewitt, Steve, Nguyen, Mary Trang, Napuli, Alberto, Barrett, Lynn, Buchko, Garry W., Stacy, Robin, Myler, Peter J., Stewart, Lance J., Manoil, Colin, Van Voorhis, Wesley C.
Argitaratua 2013

Increasing the Structural Coverage of Tuberculosis Drug Targets

nork Baugh, Loren, Phan, Isabelle, Begley, Darren W., Clifton, Matthew C., Armour, Brianna, Dranow, David M., Taylor, Brandy M., Muruthi, Marvin M., Abendroth, Jan, Fairman, James W., Fox, David, Dieterich, Shellie H., Staker, Bart L., Gardberg, Anna S., Choi, Ryan, Hewitt, Stephen N., Napuli, Alberto J., Myers, Janette, Barrett, Lynn K., Zhang, Yang, Ferrell, Micah, Mundt, Elizabeth, Thompkins, Katie, Tran, Ngoc, Lyons-Abbott, Sally, Abramov, Ariel, Sekar, Aarthi, Serbzhinskiy, Dmitri, Lorimer, Don, Buchko, Garry W., Stacy, Robin, Stewart, Lance J., Edwards, Thomas E., Van Voorhis, Wesley C., Myler, Peter J.
Argitaratua izan da Tuberculosis (Edinb) (2014)