Isotype switching: Mouse IgG3 constant region drives increased affinity for polysaccharide antigens

Por Harmer, Nicholas J., Chahwan, Richard
Publicado no Virulence (2016)

Studying the role of heparin in the formation of FGF1-FGFR2 complexes using gel chromatography

Por Robinson, Christopher J, Harmer, Nicholas J, Blundell, Tom L, Gallagher, John T
Publicado em 2004

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

Por Vivoli, Mirella, Novak, Halina R., Littlechild, Jennifer A., Harmer, Nicholas J.
Publicado no J Vis Exp (2014)

Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme

Por Vivoli, Mirella, Ayres, Emily, Beaumont, Edward, Isupov, Michail N., Harmer, Nicholas J.
Publicado em 2013

Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase

Por Schuster, Martin, Treitschke, Steffi, Kilaru, Sreedhar, Molloy, Justin, Harmer, Nicholas J, Steinberg, Gero
Publicado em 2012

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors

Por Blaszczyk, Michal, Harmer, Nicholas J., Chirgadze, Dimitri Y., Ascher, David B., Blundell, Tom L.
Publicado no Prog Biophys Mol Biol (2015)

Cloning, expression, purification and preliminary crystallographic analysis of the short-chain dehydrogenase enzymes WbmF, WbmG and WbmH from Bordetella bronchiseptica

Por Harmer, Nicholas J., King, Jerry D., Palmer, Colin M., Preston, Andrew, Maskell, Duncan J., Blundell, Tom L.
Publicado em 2007

The structure of a Burkholderia pseudomallei immunophilin–inhibitor complex reveals new approaches to antimicrobial development

Por Norville, Isobel H., O'Shea, Katherine, Sarkar-Tyson, Mitali, Zheng, Suxin, Titball, Richard W., Varani, Gabriele, Harmer, Nicholas J.
Publicado em 2011

Characterization of Carboxylic Acid Reductases as Enzymes in the Toolbox for Synthetic Chemistry

Por Finnigan, William, Thomas, Adam, Cromar, Holly, Gough, Ben, Snajdrova, Radka, Adams, Joseph P., Littlechild, Jennifer A., Harmer, Nicholas J.
Publicado no ChemCatChem (2017)

Multimers of the fibroblast growth factor (FGF)–FGF receptor–saccharide complex are formed on long oligomers of heparin

Por Harmer, Nicholas J., Robinson, Christopher J., Adam, Lucy E., Ilag, Leopold L., Robinson, Carol V., Gallagher, John T., Blundell, Tom L.
Publicado em 2006

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery

Por Vivoli, Mirella, Isupov, Michail N., Nicholas, Rebecca, Hill, Andrew, Scott, Andrew E., Kosma, Paul, Prior, Joann L., Harmer, Nicholas J.
Publicado no Chem Biol (2015)

Predicting Protein Function from Structure—The Roles of Short-chain Dehydrogenase/Reductase Enzymes in Bordetella O-antigen Biosynthesis

Por King, Jerry D., Harmer, Nicholas J., Preston, Andrew, Palmer, Colin M., Rejzek, Martin, Field, Robert A., Blundell, Tom L., Maskell, Duncan J.
Publicado em 2007

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery

Por Blundell, Tom L, Sibanda, Bancinyane L, Montalvão, Rinaldo Wander, Brewerton, Suzanne, Chelliah, Vijayalakshmi, Worth, Catherine L, Harmer, Nicholas J, Davies, Owen, Burke, David
Publicado em 2006

A Burkholderia pseudomallei Macrophage Infectivity Potentiator-Like Protein Has Rapamycin-Inhibitable Peptidylprolyl Isomerase Activity and Pleiotropic Effects on Virulence

Por Norville, Isobel H., Harmer, Nicholas J., Harding, Sarah V., Fischer, Gunter, Keith, Karen E., Brown, Katherine A., Sarkar-Tyson, Mitali, Titball, Richard W.
Publicado em 2011

Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site

Por Sayer, Christopher, Finnigan, William, Isupov, Michail N., Levisson, Mark, Kengen, Servé W. M., van der Oost, John, Harmer, Nicholas J., Littlechild, Jennifer A.
Publicado no Sci Rep (2016)

Effect of Substance P in Staphylococcus aureus and Staphylococcus epidermidis Virulence: Implication for Skin Homeostasis

Por N'Diaye, Awa, Mijouin, Lily, Hillion, Mélanie, Diaz, Suraya, Konto-Ghiorghi, Yoan, Percoco, Giuseppe, Chevalier, Sylvie, Lefeuvre, Luc, Harmer, Nicholas J., Lesouhaitier, Olivier, Feuilloley, Marc G. J.
Publicado no Front Microbiol (2016)

Pseudomonas aeruginosa Expresses a Functional Human Natriuretic Peptide Receptor Ortholog: Involvement in Biofilm Formation

Por Rosay, Thibaut, Bazire, Alexis, Diaz, Suraya, Clamens, Thomas, Blier, Anne-Sophie, Mijouin, Lily, Hoffmann, Brice, Sergent, Jacques-Aurélien, Bouffartigues, Emeline, Boireau, Wilfrid, Vieillard, Julien, Hulen, Christian, Dufour, Alain, Harmer, Nicholas J., Feuilloley, Marc G. J., Lesouhaitier, Olivier
Publicado no mBio (2015)

A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial Immunophilins

Por Begley, Darren W., Fox, David, Jenner, Dominic, Juli, Christina, Pierce, Phillip G., Abendroth, Jan, Muruthi, Muigai, Safford, Kris, Anderson, Vanessa, Atkins, Kateri, Barnes, Steve R., Moen, Spencer O., Raymond, Amy C., Stacy, Robin, Myler, Peter J., Staker, Bart L., Harmer, Nicholas J., Norville, Isobel H., Holzgrabe, Ulrike, Sarkar-Tyson, Mitali, Edwards, Thomas E., Lorimer, Donald D.
Publicado em 2014