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A small molecule probe induces a conformation in HIV TAR RNA capable of binding drug-like fragments
The HIV-1 TAR/Tat interaction is a potentially valuable target for treating HIV infection, but efforts to develop TAR-binding antiviral drugs have not yet yielded a successful candidate for clinical development. In this work, we describe a novel approach towards screening fragments against RNA that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140652/ https://ncbi.nlm.nih.gov/pubmed/21763501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.039 |
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