Development of Small Molecules with a Non-Canonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA

Small molecules that bind to RNA potently and specifically are relatively rare. The study of molecules that bind to the HIV-1 transactivation response (TAR) hairpin, a cis-acting HIV genomic element, has long been an important model system for the chemistry of targeting RNA. Here we report the synth...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Abulwerdi, Fardokht A., Shortridge, Matthew D., Sztuba-Solinska, Joanna, Wilson, Robert, Le Grice, Stuart F. J., Varani, Gabriele, Schneekloth, John S.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5525537/
https://ncbi.nlm.nih.gov/pubmed/28002966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01450
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