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Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping

Solution state nuclear magnetic resonance (NMR) is a versatile tool for the study of binding interactions between small molecules and macromolecular targets. We applied ligand-based NMR techniques to the study of human thymidylate synthase (hTS) using known nanomolar inhibitors and a library of smal...

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Detalhes bibliográficos
Main Authors: Begley, Darren W., Zheng, Suxin, Varani, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918687/
https://ncbi.nlm.nih.gov/pubmed/20626411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.01010.x
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