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1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery
WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction between a ligand and a protein and is now well-established as a screening technique for fragment-based lead discovery. Here we develop and assess a protocol to derive ligand epitope mapping from WaterLOGSY data and...
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| Publié dans: | J Enzyme Inhib Med Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6691826/ https://ncbi.nlm.nih.gov/pubmed/31286785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1636235 |
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