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Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents
The fragment FOL7185 (compound 17) was found to be a hit against IspD and IspE enzymes isolated from bacteria, and a series of analogs containing the pyrazolopyrimidine core were synthesized. The majority of these compounds inhibited the growth of Burkholderia thailandensis (Bt) and Pseudomonas aeru...
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| Publicado no: | Bioorg Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4764408/ https://ncbi.nlm.nih.gov/pubmed/26584881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.096 |
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