Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents

The fragment FOL7185 (compound 17) was found to be a hit against IspD and IspE enzymes isolated from bacteria, and a series of analogs containing the pyrazolopyrimidine core were synthesized. The majority of these compounds inhibited the growth of Burkholderia thailandensis (Bt) and Pseudomonas aeru...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Goshu, Gashaw M., Ghose, Debarati, Bain, Joy M., Pierce, Phillip G., Begley, Darren W., Hewitt, Stephen N., Udell, Hannah S., Myler, Peter J., Meganathan, R, Hagen, Timothy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764408/
https://ncbi.nlm.nih.gov/pubmed/26584881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.096
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