Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase

Enzymes in the methylerythritol phosphate pathway make attractive targets for antibacterial activity due to their importance in isoprenoid biosynthesis and the absence of the pathway in mammals. The fifth enzyme in the pathway, 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase (IspF), contains a...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Watkins, Sydney M., Ghose, Debarati, Blain, Joy M., Grote, Dakota L., Luan, Chi-Hao, Clare, Michael, Meganathan, R., Horn, James R., Hagen, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006361/
https://ncbi.nlm.nih.gov/pubmed/31521478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126660
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