Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase

Enzymes in the methylerythritol phosphate pathway make attractive targets for antibacterial activity due to their importance in isoprenoid biosynthesis and the absence of the pathway in mammals. The fifth enzyme in the pathway, 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase (IspF), contains a...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Watkins, Sydney M., Ghose, Debarati, Blain, Joy M., Grote, Dakota L., Luan, Chi-Hao, Clare, Michael, Meganathan, R., Horn, James R., Hagen, Timothy J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006361/
https://ncbi.nlm.nih.gov/pubmed/31521478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126660
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