ET-35 PACRITINIB: A NOVEL JAK/STAT INHIBITOR WITH TRANSLATIONAL RELEVANCE FOR GBM

od Luchman, Artee, Aman, Ahmed, Al-Awar, Rima, Weiss, Samuel
Izdano 2014

Small molecules reveal an alternative mechanism of Bax activation

od Brahmbhatt, Hetal, Uehling, David, Al-awar, Rima, Leber, Brian, Andrews, David
izdano v Biochem J (2016)

Asymmetric Synthesis of All the Known Phlegmarine Alkaloids

od Wolfe, Bradley H., Libby, Adam H., Al-awar, Rima S., Foti, Christopher J., Comins, Daniel L.
Izdano 2010

Use of Kinase Inhibitors to Correct ΔF508-CFTR Function

od Trzcińska-Daneluti, Agata M., Nguyen, Leo, Jiang, Chong, Fladd, Christopher, Uehling, David, Prakesch, Michael, Al-awar, Rima, Rotin, Daniela
Izdano 2012

BRAIN TUMOUR INITIATING CELLS AND TARGETING STAT3 ONCOGENIC SIGNALLING IN GBM

od Weiss, Samuel, Nguyen, Stephanie, Luchman, Artee, Grinshtein, Natalie, Stechishin, Owen, Aman, Ahmed, Uehling, David, al-Awar, Rima, Kaplan, David
Izdano 2014

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence

od Ganesh, Ahil N., Aman, Ahmed, Logie, Jennifer, Barthel, Ben L., Cogan, Peter, Al-awar, Rima, Koch, Tad H., Shoichet, Brian K., Shoichet, Molly S.
izdano v ACS Chem Biol (2019)

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

od Gwynne, William D., Shakeel, Mirza S., Girgis-Gabardo, Adele, Kim, Kwang H., Ford, Emily, Dvorkin-Gheva, Anna, Aarts, Craig, Isaac, Methvin, Al-awar, Rima, Hassell, John A.
izdano v BMC Cancer (2020)

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

od Yu, Wenyu, Smil, David, Li, Fengling, Tempel, Wolfram, Fedorov, Oleg, Nguyen, Kong T., Bolshan, Yuri, Al-Awar, Rima, Knapp, Stefan, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Schapira, Matthieu
izdano v Bioorg Med Chem (2013)

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

od Babichev, Yael, Kabaroff, Leah, Datti, Alessandro, Uehling, David, Isaac, Methvin, Al-awar, Rima, Prakesch, Michael, Sun, Ren X., Boutros, Paul C., Venier, Rosemarie, Dickson, Brendan C., Gladdy, Rebecca A.
izdano v J Transl Med (2016)

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

od Rotin, Lianne E., MacLean, Neil, Aman, Ahmed, Gronda, Marcela, Lin, Feng-Hsu, Hurren, Rose, Wang, XiaoMing, Wrana, Jeffrey L, Datti, Alessandro, Al-awar, Rima, Minden, Mark D., Schimmer, Aaron D.
izdano v Haematologica (2016)

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

od Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong-Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al-awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad
izdano v EMBO Mol Med (2014)

ATPS-28 COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

od Grinshtein, Natalie, Rioseco, Constanza, Uehling, David, Aman, Ahmed, Luchman, Artee, Senger, Donna, Robbins, Steve, Cairncross, Greg, Datti, Alessandro, Wrana, Jeff, Jones, Steve, Marra, Marco, Moran, Mike, Al-awar, Rima, Weiss, Samuel, Kaplan, David
izdano v Neuro Oncol (2015)

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

od Barghout, Samir H., Aman, Ahmed, Nouri, Kazem, Blatman, Zachary, Arevalo, Karen, Thomas, Geethu E., MacLean, Neil, Hurren, Rose, Ketela, Troy, Saini, Mehakpreet, Abohawya, Moustafa, Kiyota, Taira, Al-Awar, Rima, Schimmer, Aaron D.
izdano v JCI Insight (2021)

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

od Zhu, Jiajun, Sammons, Morgan A., Donahue, Greg, Dou, Zhixun, Vedadi, Masoud, Getlik, Matthaeus, Barsyte-Lovejoy, Dalia, Al-Awar, Rima, Katona, Bryson W., Shilatifard, Ali, Huang, Jing, Hua, Xianxin, Arrowsmith, Cheryl H., Berger, Shelley L.
izdano v Nature (2015)

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

od Hammoud, Lamis, Adams, Jessica R., Loch, Amanda J., Marcellus, Richard C., Uehling, David E., Aman, Ahmed, Fladd, Christopher, McKee, Trevor D., Jo, Christine E.B., Al-Awar, Rima, Egan, Sean E., Rossant, Janet
izdano v Stem Cell Reports (2016)

COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS AND NOVEL TARGETS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

od Kaplan, David, Grinshtein, Natalie, Rioseco, Constanza, Luchman, Artee, Datti, Alessandro, Aman, Ahmed, Uehling, David, Prakesch, Michael, Wrana, Jeff, Cairncross, Greg, Shen, Yaoqing, Jones, Steve, Marra, Marco, Senger, Donna, Robbins, Steve, Al-Awar, Rima, Moran, Mike, Weiss, Samuel
Izdano 2014

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

od Zhang, Qiangmin, Xiao, Kunhong, Paredes, José M., Mamonova, Tatyana, Sneddon, W. Bruce, Liu, Hongda, Wang, Dawei, Li, Sheng, McGarvey, Jennifer C., Uehling, David, Al-awar, Rima, Joseph, Babu, Jean-Alphonse, Frederic, Orte, Angel, Friedman, Peter A.
izdano v J Biol Chem (2019)

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

od Bolshan, Yuri, Getlik, Matthäus, Kuznetsova, Ekaterina, Wasney, Gregory A., Hajian, Taraneh, Poda, Gennadiy, Nguyen, Kong T., Wu, Hong, Dombrovski, Ludmila, Dong, Aiping, Senisterra, Guillermo, Schapira, Matthieu, Arrowsmith, Cheryl H., Brown, Peter J., Al-awar, Rima, Vedadi, Masoud, Smil, David
Izdano 2013

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

od Ensan, Deeba, Smil, David, Zepeda-Velázquez, Carlos A., Panagopoulos, Dimitrios, Wong, Jong Fu, Williams, Eleanor P., Adamson, Roslin, Bullock, Alex N., Kiyota, Taira, Aman, Ahmed, Roberts, Owen G., Edwards, Aled M., O’Meara, Jeff A., Isaac, Methvin B., Al-awar, Rima
izdano v J Med Chem (2020)

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

od Haftchenary, Sina, Luchman, H. Artee, Jouk, Andriana O., Veloso, Anthony J., Page, Brent D. G., Cheng, Xin Ran, Dawson, Sean S., Grinshtein, Natalie, Shahani, Vijay M., Kerman, Kagan, Kaplan, David R., Griffin, Carly, Aman, Ahmed M., Al-awar, Rima, Weiss, Samuel, Gunning, Patrick T.
Izdano 2013