ET-35 PACRITINIB: A NOVEL JAK/STAT INHIBITOR WITH TRANSLATIONAL RELEVANCE FOR GBM

door Luchman, Artee, Aman, Ahmed, Al-Awar, Rima, Weiss, Samuel
Gepubliceerd in 2014

Small molecules reveal an alternative mechanism of Bax activation

door Brahmbhatt, Hetal, Uehling, David, Al-awar, Rima, Leber, Brian, Andrews, David
Gepubliceerd in Biochem J (2016)

Asymmetric Synthesis of All the Known Phlegmarine Alkaloids

door Wolfe, Bradley H., Libby, Adam H., Al-awar, Rima S., Foti, Christopher J., Comins, Daniel L.
Gepubliceerd in 2010

Use of Kinase Inhibitors to Correct ΔF508-CFTR Function

door Trzcińska-Daneluti, Agata M., Nguyen, Leo, Jiang, Chong, Fladd, Christopher, Uehling, David, Prakesch, Michael, Al-awar, Rima, Rotin, Daniela
Gepubliceerd in 2012

BRAIN TUMOUR INITIATING CELLS AND TARGETING STAT3 ONCOGENIC SIGNALLING IN GBM

door Weiss, Samuel, Nguyen, Stephanie, Luchman, Artee, Grinshtein, Natalie, Stechishin, Owen, Aman, Ahmed, Uehling, David, al-Awar, Rima, Kaplan, David
Gepubliceerd in 2014

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence

door Ganesh, Ahil N., Aman, Ahmed, Logie, Jennifer, Barthel, Ben L., Cogan, Peter, Al-awar, Rima, Koch, Tad H., Shoichet, Brian K., Shoichet, Molly S.
Gepubliceerd in ACS Chem Biol (2019)

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

door Gwynne, William D., Shakeel, Mirza S., Girgis-Gabardo, Adele, Kim, Kwang H., Ford, Emily, Dvorkin-Gheva, Anna, Aarts, Craig, Isaac, Methvin, Al-awar, Rima, Hassell, John A.
Gepubliceerd in BMC Cancer (2020)

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

door Yu, Wenyu, Smil, David, Li, Fengling, Tempel, Wolfram, Fedorov, Oleg, Nguyen, Kong T., Bolshan, Yuri, Al-Awar, Rima, Knapp, Stefan, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Schapira, Matthieu
Gepubliceerd in Bioorg Med Chem (2013)

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

door Babichev, Yael, Kabaroff, Leah, Datti, Alessandro, Uehling, David, Isaac, Methvin, Al-awar, Rima, Prakesch, Michael, Sun, Ren X., Boutros, Paul C., Venier, Rosemarie, Dickson, Brendan C., Gladdy, Rebecca A.
Gepubliceerd in J Transl Med (2016)

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

door Rotin, Lianne E., MacLean, Neil, Aman, Ahmed, Gronda, Marcela, Lin, Feng-Hsu, Hurren, Rose, Wang, XiaoMing, Wrana, Jeffrey L, Datti, Alessandro, Al-awar, Rima, Minden, Mark D., Schimmer, Aaron D.
Gepubliceerd in Haematologica (2016)

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

door Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong-Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al-awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad
Gepubliceerd in EMBO Mol Med (2014)

ATPS-28 COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

door Grinshtein, Natalie, Rioseco, Constanza, Uehling, David, Aman, Ahmed, Luchman, Artee, Senger, Donna, Robbins, Steve, Cairncross, Greg, Datti, Alessandro, Wrana, Jeff, Jones, Steve, Marra, Marco, Moran, Mike, Al-awar, Rima, Weiss, Samuel, Kaplan, David
Gepubliceerd in Neuro Oncol (2015)

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

door Barghout, Samir H., Aman, Ahmed, Nouri, Kazem, Blatman, Zachary, Arevalo, Karen, Thomas, Geethu E., MacLean, Neil, Hurren, Rose, Ketela, Troy, Saini, Mehakpreet, Abohawya, Moustafa, Kiyota, Taira, Al-Awar, Rima, Schimmer, Aaron D.
Gepubliceerd in JCI Insight (2021)

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

door Zhu, Jiajun, Sammons, Morgan A., Donahue, Greg, Dou, Zhixun, Vedadi, Masoud, Getlik, Matthaeus, Barsyte-Lovejoy, Dalia, Al-Awar, Rima, Katona, Bryson W., Shilatifard, Ali, Huang, Jing, Hua, Xianxin, Arrowsmith, Cheryl H., Berger, Shelley L.
Gepubliceerd in Nature (2015)

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

door Hammoud, Lamis, Adams, Jessica R., Loch, Amanda J., Marcellus, Richard C., Uehling, David E., Aman, Ahmed, Fladd, Christopher, McKee, Trevor D., Jo, Christine E.B., Al-Awar, Rima, Egan, Sean E., Rossant, Janet
Gepubliceerd in Stem Cell Reports (2016)

COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS AND NOVEL TARGETS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

door Kaplan, David, Grinshtein, Natalie, Rioseco, Constanza, Luchman, Artee, Datti, Alessandro, Aman, Ahmed, Uehling, David, Prakesch, Michael, Wrana, Jeff, Cairncross, Greg, Shen, Yaoqing, Jones, Steve, Marra, Marco, Senger, Donna, Robbins, Steve, Al-Awar, Rima, Moran, Mike, Weiss, Samuel
Gepubliceerd in 2014

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

door Zhang, Qiangmin, Xiao, Kunhong, Paredes, José M., Mamonova, Tatyana, Sneddon, W. Bruce, Liu, Hongda, Wang, Dawei, Li, Sheng, McGarvey, Jennifer C., Uehling, David, Al-awar, Rima, Joseph, Babu, Jean-Alphonse, Frederic, Orte, Angel, Friedman, Peter A.
Gepubliceerd in J Biol Chem (2019)

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

door Bolshan, Yuri, Getlik, Matthäus, Kuznetsova, Ekaterina, Wasney, Gregory A., Hajian, Taraneh, Poda, Gennadiy, Nguyen, Kong T., Wu, Hong, Dombrovski, Ludmila, Dong, Aiping, Senisterra, Guillermo, Schapira, Matthieu, Arrowsmith, Cheryl H., Brown, Peter J., Al-awar, Rima, Vedadi, Masoud, Smil, David
Gepubliceerd in 2013

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

door Ensan, Deeba, Smil, David, Zepeda-Velázquez, Carlos A., Panagopoulos, Dimitrios, Wong, Jong Fu, Williams, Eleanor P., Adamson, Roslin, Bullock, Alex N., Kiyota, Taira, Aman, Ahmed, Roberts, Owen G., Edwards, Aled M., O’Meara, Jeff A., Isaac, Methvin B., Al-awar, Rima
Gepubliceerd in J Med Chem (2020)

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

door Haftchenary, Sina, Luchman, H. Artee, Jouk, Andriana O., Veloso, Anthony J., Page, Brent D. G., Cheng, Xin Ran, Dawson, Sean S., Grinshtein, Natalie, Shahani, Vijay M., Kerman, Kagan, Kaplan, David R., Griffin, Carly, Aman, Ahmed M., Al-awar, Rima, Weiss, Samuel, Gunning, Patrick T.
Gepubliceerd in 2013