ET-35 PACRITINIB: A NOVEL JAK/STAT INHIBITOR WITH TRANSLATIONAL RELEVANCE FOR GBM

Tekijä Luchman, Artee, Aman, Ahmed, Al-Awar, Rima, Weiss, Samuel
Julkaistu 2014

Small molecules reveal an alternative mechanism of Bax activation

Tekijä Brahmbhatt, Hetal, Uehling, David, Al-awar, Rima, Leber, Brian, Andrews, David
Julkaisussa Biochem J (2016)

Asymmetric Synthesis of All the Known Phlegmarine Alkaloids

Tekijä Wolfe, Bradley H., Libby, Adam H., Al-awar, Rima S., Foti, Christopher J., Comins, Daniel L.
Julkaistu 2010

Use of Kinase Inhibitors to Correct ΔF508-CFTR Function

Tekijä Trzcińska-Daneluti, Agata M., Nguyen, Leo, Jiang, Chong, Fladd, Christopher, Uehling, David, Prakesch, Michael, Al-awar, Rima, Rotin, Daniela
Julkaistu 2012

BRAIN TUMOUR INITIATING CELLS AND TARGETING STAT3 ONCOGENIC SIGNALLING IN GBM

Tekijä Weiss, Samuel, Nguyen, Stephanie, Luchman, Artee, Grinshtein, Natalie, Stechishin, Owen, Aman, Ahmed, Uehling, David, al-Awar, Rima, Kaplan, David
Julkaistu 2014

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence

Tekijä Ganesh, Ahil N., Aman, Ahmed, Logie, Jennifer, Barthel, Ben L., Cogan, Peter, Al-awar, Rima, Koch, Tad H., Shoichet, Brian K., Shoichet, Molly S.
Julkaisussa ACS Chem Biol (2019)

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

Tekijä Gwynne, William D., Shakeel, Mirza S., Girgis-Gabardo, Adele, Kim, Kwang H., Ford, Emily, Dvorkin-Gheva, Anna, Aarts, Craig, Isaac, Methvin, Al-awar, Rima, Hassell, John A.
Julkaisussa BMC Cancer (2020)

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

Tekijä Yu, Wenyu, Smil, David, Li, Fengling, Tempel, Wolfram, Fedorov, Oleg, Nguyen, Kong T., Bolshan, Yuri, Al-Awar, Rima, Knapp, Stefan, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Schapira, Matthieu
Julkaisussa Bioorg Med Chem (2013)

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

Tekijä Babichev, Yael, Kabaroff, Leah, Datti, Alessandro, Uehling, David, Isaac, Methvin, Al-awar, Rima, Prakesch, Michael, Sun, Ren X., Boutros, Paul C., Venier, Rosemarie, Dickson, Brendan C., Gladdy, Rebecca A.
Julkaisussa J Transl Med (2016)

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

Tekijä Rotin, Lianne E., MacLean, Neil, Aman, Ahmed, Gronda, Marcela, Lin, Feng-Hsu, Hurren, Rose, Wang, XiaoMing, Wrana, Jeffrey L, Datti, Alessandro, Al-awar, Rima, Minden, Mark D., Schimmer, Aaron D.
Julkaisussa Haematologica (2016)

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

Tekijä Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong-Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al-awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad
Julkaisussa EMBO Mol Med (2014)

ATPS-28 COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

Tekijä Grinshtein, Natalie, Rioseco, Constanza, Uehling, David, Aman, Ahmed, Luchman, Artee, Senger, Donna, Robbins, Steve, Cairncross, Greg, Datti, Alessandro, Wrana, Jeff, Jones, Steve, Marra, Marco, Moran, Mike, Al-awar, Rima, Weiss, Samuel, Kaplan, David
Julkaisussa Neuro Oncol (2015)

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

Tekijä Barghout, Samir H., Aman, Ahmed, Nouri, Kazem, Blatman, Zachary, Arevalo, Karen, Thomas, Geethu E., MacLean, Neil, Hurren, Rose, Ketela, Troy, Saini, Mehakpreet, Abohawya, Moustafa, Kiyota, Taira, Al-Awar, Rima, Schimmer, Aaron D.
Julkaisussa JCI Insight (2021)

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

Tekijä Zhu, Jiajun, Sammons, Morgan A., Donahue, Greg, Dou, Zhixun, Vedadi, Masoud, Getlik, Matthaeus, Barsyte-Lovejoy, Dalia, Al-Awar, Rima, Katona, Bryson W., Shilatifard, Ali, Huang, Jing, Hua, Xianxin, Arrowsmith, Cheryl H., Berger, Shelley L.
Julkaisussa Nature (2015)

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

Tekijä Hammoud, Lamis, Adams, Jessica R., Loch, Amanda J., Marcellus, Richard C., Uehling, David E., Aman, Ahmed, Fladd, Christopher, McKee, Trevor D., Jo, Christine E.B., Al-Awar, Rima, Egan, Sean E., Rossant, Janet
Julkaisussa Stem Cell Reports (2016)

COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS AND NOVEL TARGETS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

Tekijä Kaplan, David, Grinshtein, Natalie, Rioseco, Constanza, Luchman, Artee, Datti, Alessandro, Aman, Ahmed, Uehling, David, Prakesch, Michael, Wrana, Jeff, Cairncross, Greg, Shen, Yaoqing, Jones, Steve, Marra, Marco, Senger, Donna, Robbins, Steve, Al-Awar, Rima, Moran, Mike, Weiss, Samuel
Julkaistu 2014

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

Tekijä Zhang, Qiangmin, Xiao, Kunhong, Paredes, José M., Mamonova, Tatyana, Sneddon, W. Bruce, Liu, Hongda, Wang, Dawei, Li, Sheng, McGarvey, Jennifer C., Uehling, David, Al-awar, Rima, Joseph, Babu, Jean-Alphonse, Frederic, Orte, Angel, Friedman, Peter A.
Julkaisussa J Biol Chem (2019)

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

Tekijä Bolshan, Yuri, Getlik, Matthäus, Kuznetsova, Ekaterina, Wasney, Gregory A., Hajian, Taraneh, Poda, Gennadiy, Nguyen, Kong T., Wu, Hong, Dombrovski, Ludmila, Dong, Aiping, Senisterra, Guillermo, Schapira, Matthieu, Arrowsmith, Cheryl H., Brown, Peter J., Al-awar, Rima, Vedadi, Masoud, Smil, David
Julkaistu 2013

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

Tekijä Ensan, Deeba, Smil, David, Zepeda-Velázquez, Carlos A., Panagopoulos, Dimitrios, Wong, Jong Fu, Williams, Eleanor P., Adamson, Roslin, Bullock, Alex N., Kiyota, Taira, Aman, Ahmed, Roberts, Owen G., Edwards, Aled M., O’Meara, Jeff A., Isaac, Methvin B., Al-awar, Rima
Julkaisussa J Med Chem (2020)

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

Tekijä Haftchenary, Sina, Luchman, H. Artee, Jouk, Andriana O., Veloso, Anthony J., Page, Brent D. G., Cheng, Xin Ran, Dawson, Sean S., Grinshtein, Natalie, Shahani, Vijay M., Kerman, Kagan, Kaplan, David R., Griffin, Carly, Aman, Ahmed M., Al-awar, Rima, Weiss, Samuel, Gunning, Patrick T.
Julkaistu 2013