ET-35 PACRITINIB: A NOVEL JAK/STAT INHIBITOR WITH TRANSLATIONAL RELEVANCE FOR GBM

nork Luchman, Artee, Aman, Ahmed, Al-Awar, Rima, Weiss, Samuel
Argitaratua 2014

Small molecules reveal an alternative mechanism of Bax activation

nork Brahmbhatt, Hetal, Uehling, David, Al-awar, Rima, Leber, Brian, Andrews, David
Argitaratua izan da Biochem J (2016)

Asymmetric Synthesis of All the Known Phlegmarine Alkaloids

nork Wolfe, Bradley H., Libby, Adam H., Al-awar, Rima S., Foti, Christopher J., Comins, Daniel L.
Argitaratua 2010

Use of Kinase Inhibitors to Correct ΔF508-CFTR Function

nork Trzcińska-Daneluti, Agata M., Nguyen, Leo, Jiang, Chong, Fladd, Christopher, Uehling, David, Prakesch, Michael, Al-awar, Rima, Rotin, Daniela
Argitaratua 2012

BRAIN TUMOUR INITIATING CELLS AND TARGETING STAT3 ONCOGENIC SIGNALLING IN GBM

nork Weiss, Samuel, Nguyen, Stephanie, Luchman, Artee, Grinshtein, Natalie, Stechishin, Owen, Aman, Ahmed, Uehling, David, al-Awar, Rima, Kaplan, David
Argitaratua 2014

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence

nork Ganesh, Ahil N., Aman, Ahmed, Logie, Jennifer, Barthel, Ben L., Cogan, Peter, Al-awar, Rima, Koch, Tad H., Shoichet, Brian K., Shoichet, Molly S.
Argitaratua izan da ACS Chem Biol (2019)

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

nork Gwynne, William D., Shakeel, Mirza S., Girgis-Gabardo, Adele, Kim, Kwang H., Ford, Emily, Dvorkin-Gheva, Anna, Aarts, Craig, Isaac, Methvin, Al-awar, Rima, Hassell, John A.
Argitaratua izan da BMC Cancer (2020)

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

nork Yu, Wenyu, Smil, David, Li, Fengling, Tempel, Wolfram, Fedorov, Oleg, Nguyen, Kong T., Bolshan, Yuri, Al-Awar, Rima, Knapp, Stefan, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Schapira, Matthieu
Argitaratua izan da Bioorg Med Chem (2013)

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

nork Babichev, Yael, Kabaroff, Leah, Datti, Alessandro, Uehling, David, Isaac, Methvin, Al-awar, Rima, Prakesch, Michael, Sun, Ren X., Boutros, Paul C., Venier, Rosemarie, Dickson, Brendan C., Gladdy, Rebecca A.
Argitaratua izan da J Transl Med (2016)

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

nork Rotin, Lianne E., MacLean, Neil, Aman, Ahmed, Gronda, Marcela, Lin, Feng-Hsu, Hurren, Rose, Wang, XiaoMing, Wrana, Jeffrey L, Datti, Alessandro, Al-awar, Rima, Minden, Mark D., Schimmer, Aaron D.
Argitaratua izan da Haematologica (2016)

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

nork Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong-Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al-awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad
Argitaratua izan da EMBO Mol Med (2014)

ATPS-28 COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

nork Grinshtein, Natalie, Rioseco, Constanza, Uehling, David, Aman, Ahmed, Luchman, Artee, Senger, Donna, Robbins, Steve, Cairncross, Greg, Datti, Alessandro, Wrana, Jeff, Jones, Steve, Marra, Marco, Moran, Mike, Al-awar, Rima, Weiss, Samuel, Kaplan, David
Argitaratua izan da Neuro Oncol (2015)

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

nork Barghout, Samir H., Aman, Ahmed, Nouri, Kazem, Blatman, Zachary, Arevalo, Karen, Thomas, Geethu E., MacLean, Neil, Hurren, Rose, Ketela, Troy, Saini, Mehakpreet, Abohawya, Moustafa, Kiyota, Taira, Al-Awar, Rima, Schimmer, Aaron D.
Argitaratua izan da JCI Insight (2021)

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

nork Zhu, Jiajun, Sammons, Morgan A., Donahue, Greg, Dou, Zhixun, Vedadi, Masoud, Getlik, Matthaeus, Barsyte-Lovejoy, Dalia, Al-Awar, Rima, Katona, Bryson W., Shilatifard, Ali, Huang, Jing, Hua, Xianxin, Arrowsmith, Cheryl H., Berger, Shelley L.
Argitaratua izan da Nature (2015)

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

nork Hammoud, Lamis, Adams, Jessica R., Loch, Amanda J., Marcellus, Richard C., Uehling, David E., Aman, Ahmed, Fladd, Christopher, McKee, Trevor D., Jo, Christine E.B., Al-Awar, Rima, Egan, Sean E., Rossant, Janet
Argitaratua izan da Stem Cell Reports (2016)

COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS AND NOVEL TARGETS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

nork Kaplan, David, Grinshtein, Natalie, Rioseco, Constanza, Luchman, Artee, Datti, Alessandro, Aman, Ahmed, Uehling, David, Prakesch, Michael, Wrana, Jeff, Cairncross, Greg, Shen, Yaoqing, Jones, Steve, Marra, Marco, Senger, Donna, Robbins, Steve, Al-Awar, Rima, Moran, Mike, Weiss, Samuel
Argitaratua 2014

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

nork Zhang, Qiangmin, Xiao, Kunhong, Paredes, José M., Mamonova, Tatyana, Sneddon, W. Bruce, Liu, Hongda, Wang, Dawei, Li, Sheng, McGarvey, Jennifer C., Uehling, David, Al-awar, Rima, Joseph, Babu, Jean-Alphonse, Frederic, Orte, Angel, Friedman, Peter A.
Argitaratua izan da J Biol Chem (2019)

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

nork Bolshan, Yuri, Getlik, Matthäus, Kuznetsova, Ekaterina, Wasney, Gregory A., Hajian, Taraneh, Poda, Gennadiy, Nguyen, Kong T., Wu, Hong, Dombrovski, Ludmila, Dong, Aiping, Senisterra, Guillermo, Schapira, Matthieu, Arrowsmith, Cheryl H., Brown, Peter J., Al-awar, Rima, Vedadi, Masoud, Smil, David
Argitaratua 2013

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

nork Ensan, Deeba, Smil, David, Zepeda-Velázquez, Carlos A., Panagopoulos, Dimitrios, Wong, Jong Fu, Williams, Eleanor P., Adamson, Roslin, Bullock, Alex N., Kiyota, Taira, Aman, Ahmed, Roberts, Owen G., Edwards, Aled M., O’Meara, Jeff A., Isaac, Methvin B., Al-awar, Rima
Argitaratua izan da J Med Chem (2020)

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

nork Haftchenary, Sina, Luchman, H. Artee, Jouk, Andriana O., Veloso, Anthony J., Page, Brent D. G., Cheng, Xin Ran, Dawson, Sean S., Grinshtein, Natalie, Shahani, Vijay M., Kerman, Kagan, Kaplan, David R., Griffin, Carly, Aman, Ahmed M., Al-awar, Rima, Weiss, Samuel, Gunning, Patrick T.
Argitaratua 2013