Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)

Por Drewry, David H., Willson, Timothy M., Zuercher, William J.
Publicado no Curr Top Med Chem (2014)

Transactivation Function-2 of Estrogen Receptor α Contains Transactivation Function-1-regulating Element

Por Arao, Yukitomo, Coons, Laurel A., Zuercher, William J., Korach, Kenneth S.
Publicado no J Biol Chem (2015)

Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor

Por Zhang, Cunyu, Creech, Katrina L., Zuercher, William J., Willson, Timothy M.
Publicado no Sci Rep (2019)

A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction

Por Drewry, David H., Wells, Carrow I., Zuercher, William J., Willson, Timothy M.
Publicado no SLAS Discov (2019)

New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)

Por Asquith, Christopher R. M., Laitinen, Tuomo, Wells, Carrow I., Tizzard, Graham J., Zuercher, William J.
Publicado no Molecules (2020)

Crystal Structure of the PXR-T1317 Complex Provides a Scaffold to Examine the Potential for Receptor Antagonism

Por Xue, Yu, Chao, Esther, Zuercher, William J., Willson, Timothy M., Collins, Jon L., Redinbo, Matthew R.
Publicado em 2006

The metabolic regulator ERRα, a downstream target of HER2/IGF-1, as a therapeutic target in breast cancer

Por Chang, Ching-yi, Kazmin, Dmitri, Jasper, Jeff S., Kunder, Rebecca, Zuercher, William J., McDonnell, Donald P.
Publicado em 2011

Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays

Por Dranchak, Patricia, MacArthur, Ryan, Guha, Rajarshi, Zuercher, William J., Drewry, David H., Auld, Douglas S., Inglese, James
Publicado em 2013

Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines

Por Asquith, Christopher R. M., Fleck, Neil, Torrice, Chad D., Crona, Daniel J., Grundner, Christoph, Zuercher, William J.
Publicado no Bioorg Med Chem Lett (2019)

Identifying the target of an antiparasitic compound in Toxoplasma using thermal proteome profiling

Por Herneisen, Alice L., Sidik, Saima M., Markus, Benedikt M., Drewry, David H., Zuercher, William J., Lourido, Sebastian
Publicado no ACS Chem Biol (2020)

High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-tran...

Por Khan, Amina S, Murray, Matthew J, Ho, Catherine M. K, Zuercher, William J, Reeves, Matthew B, Strang, Blair L
Publicado no J Gen Virol (2017)

Nuclear Receptor Signaling Atlas (): hyperlinking the nuclear receptor signaling community

Por Lanz, Rainer B., Jericevic, Zeljko, Zuercher, William J., Watkins, Chris, Steffen, David L., Margolis, Ronald, McKenna, Neil J.
Publicado em 2006

A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA

Por Schaenzer, Adam J., Wlodarchak, Nathan, Drewry, David H., Zuercher, William J., Rose, Warren E., Striker, Rob, Sauer, John-Demian
Publicado no J Biol Chem (2017)

Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data

Por Strang, Blair L., Asquith, Christopher R. M., Moshrif, Hanan F., Ho, Catherine M-K, Zuercher, William J., Al-Ali, Hassan
Publicado no PLoS One (2018)

GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against β-Lactam-Resistant Staphylococcus aureus

Por Schaenzer, Adam J., Wlodarchak, Nathan, Drewry, David H., Zuercher, William J., Rose, Warren E., Ferrer, Carla A., Sauer, John-Demian, Striker, Rob
Publicado no ACS Infect Dis (2018)

Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

Por Volpatti, Jonathan R, Endo, Yukari, Knox, Jessica, Groom, Linda, Brennan, Stephanie, Noche, Ramil, Zuercher, William J, Roy, Peter, Dirksen, Robert T, Dowling, James J
Publicado no eLife (2020)

Ligand-Dependent Regulation of the Activity of the Orphan Nuclear Receptor, Small Heterodimer Partner (SHP), in the Repression of Bile Acid Biosynthetic CYP7A1 and CYP8B1 Genes

Por Miao, Ji, Choi, Sung-E, Seok, Sun Mi, Yang, Linda, Zuercher, William J., Xu, Yong, Willson, Timothy M., Xu, H. Eric, Kemper, Jongsook Kim
Publicado em 2011

On the intractability of estrogen-related receptor α as a target for activation by small molecules

Por Hyatt, Stephen M., Lockamy, Elizabeth, Stein, Rebecca A., McDonnell, Donald P., Miller, Aaron B., Orband-Miller, Lisa A., Willson, Timothy M., Zuercher, William J.
Publicado em 2007

Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System

Por Carabajal, María Ayelén, Asquith, Christopher R. M., Laitinen, Tuomo, Tizzard, Graham J., Yim, Lucía, Rial, Analía, Chabalgoity, José A., Zuercher, William J., García Véscovi, Eleonora
Publicado no Antimicrob Agents Chemother (2019)

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)

Por Asquith, Christopher R. M., Bennett, James M., Su, Lianyong, Laitinen, Tuomo, Elkins, Jonathan M., Pickett, Julie E., Wells, Carrow I., Li, Zengbiao, Willson, Timothy M., Zuercher, William J.
Publicado no Molecules (2019)