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Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)
SGC-GAK-1 (1) is a potent, selective, cell-active chemical probe for cyclin G-associated kinase (GAK). However, 1 was rapidly metabolized in mouse liver microsomes by cytochrome P450-mediated oxidation, displaying rapid clearance in liver microsomes and in mice, which limited its utility in in vivo...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6891286/ https://ncbi.nlm.nih.gov/pubmed/31698822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24224016 |
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