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Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

4-Anilinoquinolines were identified as potent and narrow spectrum inhibitors of the cyclin G associated kinase (GAK), an important regulator of viral and bacterial entry into host cells. Optimization of the 4-anilino group and the 6,7-quinoline substituents produced GAK inhibitors with nanomolar act...

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Bibliografiske detaljer
Udgivet i:ChemMedChem
Main Authors: Asquith, Christopher R. M., Laitinen, Tuomo, Bennett, James M., Godoi, Paulo H., East, Michael P., Tizzard, Graham J., Graves, Lee M., Johnson, Gary L., Dornsife, Ronna E., Wells, Carrow I., Elkins, Jonathan M., Willson, Timothy M., Zuercher, William J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914168/
https://ncbi.nlm.nih.gov/pubmed/29072804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700663
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