Models for the Functions of Arf GAPs

por East, Michael P., Kahn, Richard A.
Publicado 2010

ARF-Like (ARL) Proteins

por Kahn, Richard A., East, Michael P., Francis, Joshua W.
Publicado en Ras Superfamily Small G Proteins: Biology and Mechanisms 2 (2014)

The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis

por Turn, Rachel E., East, Michael P., Prekeris, Rytis, Kahn, Richard A.
Publicado en Mol Biol Cell (2020)

ELMO Domains, Evolutionary and Functional Characterization of a Novel GTPase-activating Protein (GAP) Domain for Arf Protein Family GTPases

por East, Michael P., Bowzard, J. Bradford, Dacks, Joel B., Kahn, Richard A.
Publicado 2012

Characterization of Recombinant ELMOD (Cell Engulfment and Motility Domain) Proteins as GTPase-activating Proteins (GAPs) for ARF Family GTPases

por Ivanova, Anna A., East, Michael P., Yi, Slee L., Kahn, Richard A.
Publicado 2014

Development of Multifunctional Nanoparticles for Targeted Drug Delivery and Non-invasive Imaging of Therapeutic Effect

por Sajja, Hari Krishna, East, Michael P., Mao, Hui, Wang, Andrew Y., Nie, Shuming, Yang, Lily
Publicado 2009

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins

por Larkins, Christine E., Aviles, Gladys D. Gonzalez, East, Michael P., Kahn, Richard A., Caspary, Tamara
Publicado 2011

BIRC6 mediates imatinib resistance independently of Mcl-1

por Okumu, Denis O., East, Michael P., Levine, Merlin, Herring, Laura E., Zhang, Raymond, Gilbert, Thomas S. K., Litchfield, David W., Zhang, Yanping, Graves, Lee M.
Publicado en PLoS One (2017)

Lyn regulates creatine uptake in an imatinib-resistant CML cell line

por Okumu, Denis O., Aponte-Collazo, Lucas J., Dewar, Brian J., Cox, Nathan J., East, Michael P., Tech, Katherine, McDonald, Ian M., Tikunov, Andrey P., Holmuhamedov, Ekhson, Macdonald, Jeffrey M., Graves, Lee M.
Publicado en Biochim Biophys Acta Gen Subj (2019)

Arl13b and the exocyst interact synergistically in ciliogenesis

por Seixas, Cecília, Choi, Soo Young, Polgar, Noemi, Umberger, Nicole L., East, Michael P., Zuo, Xiaofeng, Moreiras, Hugo, Ghossoub, Rania, Benmerah, Alexandre, Kahn, Richard A., Fogelgren, Ben, Caspary, Tamara, Lipschutz, Joshua H., Barral, Duarte C.
Publicado en Mol Biol Cell (2016)

Mass spectrometry–based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells

por McDonald, Ian M., Grant, Gavin D., East, Michael P., Gilbert, Thomas S. K., Wilkerson, Emily M., Goldfarb, Dennis, Beri, Joshua, Herring, Laura E., Vaziri, Cyrus, Cook, Jeanette Gowen, Emanuele, Michael J., Graves, Lee M.
Publicado en J Biol Chem (2020)

Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals

por Arend, Kyle C., Lenarcic, Erik M., Vincent, Heather A., Rashid, Naim, Lazear, Eric, McDonald, Ian M., Gilbert, Thomas S. K., East, Michael P., Herring, Laura E., Johnson, Gary L., Graves, Lee M., Moorman, Nathaniel J.
Publicado en Mol Cell Proteomics (2017)

Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

por Asquith, Christopher R. M., Laitinen, Tuomo, Bennett, James M., Godoi, Paulo H., East, Michael P., Tizzard, Graham J., Graves, Lee M., Johnson, Gary L., Dornsife, Ronna E., Wells, Carrow I., Elkins, Jonathan M., Willson, Timothy M., Zuercher, William J.
Publicado en ChemMedChem (2017)

Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy

por Lipner, Matthew B., Peng, Xianlu L., Jin, Chong, Xu, Yi, Gao, Yanzhe, East, Michael P., Rashid, Naim U., Moffitt, Richard A., Herrera Loeza, Silvia G., Morrison, Ashley B., Golitz, Brian T., Vaziri, Cyrus, Graves, Lee M., Johnson, Gary L., Yeh, Jen Jen
Publicado en JCI Insight (2020)

Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer

por Collins, Kyla A.L., Stuhlmiller, Timothy J., Zawistowski, Jon S., East, Michael P., Pham, Trang T., Hall, Claire R., Goulet, Daniel R., Bevill, Samantha M., Angus, Steven P., Velarde, Sara H., Sciaky, Noah, Oprea, Tudor I., Graves, Lee M., Johnson, Gary L., Gomez, Shawn M.
Publicado en Oncotarget (2018)

Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth

por Krulikas, Linas J., McDonald, Ian M., Lee, Benjamin, Okumu, Denis O., East, Michael P., Gilbert, Thomas S. K., Herring, Laura E., Golitz, Brian T., Wells, Carrow I., Axtman, Allison D., Zuercher, William J., Willson, Timothy M., Kireev, Dmitri, Yeh, Jen Jen, Johnson, Gary L., Baines, Antonio T., Graves, Lee M.
Publicado en SLAS Discov (2018)

Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues

por Graves, Paul R., Aponte-Collazo, Lucas J., Fennell, Emily M. J., Graves, Adam C., Hale, Andrew E., Dicheva, Nedyalka, Herring, Laura E., Gilbert, Thomas S. K., East, Michael P., McDonald, Ian M., Lockett, Matthew R., Ashamalla, Hani, Moorman, Nathaniel J., Karanewsky, Donald S., Iwanowicz, Edwin J., Holmuhamedov, Ekhson, Graves, Lee M.
Publicado en ACS Chem Biol (2019)

SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)

por Asquith, Christopher R. M., Berger, Benedict-Tilman, Wan, Jing, Bennett, James M., Capuzzi, Stephen J., Crona, Daniel J., Drewry, David H., East, Michael P., Elkins, Jonathan M., Fedrov, Oleg, Godoi, Paulo H., Hunter, Debra M., Knapp, Stefan, Müller, Susanne, Torrice, Chad D., Wells, Carrow I., Earp, H. Shelton, Willson, Timothy M., Zuercher, William J.
Publicado en J Med Chem (2019)

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

por Garcia-Recio, Susana, Thennavan, Aatish, East, Michael P., Parker, Joel S., Cejalvo, Juan M., Garay, Joseph P., Hollern, Daniel P., He, Xiaping, Mott, Kevin R., Galván, Patricia, Fan, Cheng, Selitsky, Sara R., Coffey, Alisha R., Marron, David, Brasó-Maristany, Fara, Burgués, Octavio, Albanell, Joan, Rojo, Federico, Lluch, Ana, de Dueñas, Eduardo Martinez, Rosen, Jeffery M., Johnson, Gary L., Carey, Lisa A., Prat, Aleix, Perou, Charles M.
Publicado en J Clin Invest (2020)

FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036

por Angus, Steven P., Stuhlmiller, Timothy J., Mehta, Gaurav, Bevill, Samantha M., Goulet, Daniel R., Olivares-Quintero, J. Felix, East, Michael P., Tanioka, Maki, Zawistowski, Jon S., Singh, Darshan, Sciaky, Noah, Chen, Xin, He, Xiaping, Rashid, Naim U., Chollet-Hinton, Lynn, Fan, Cheng, Soloway, Matthew G., Spears, Patricia A., Jefferys, Stuart, Parker, Joel S., Gallagher, Kristalyn K., Forero-Torres, Andres, Krop, Ian E., Thompson, Alastair M., Murthy, Rashmi, Gatza, Michael L., Perou, Charles M., Earp, H. Shelton, Carey, Lisa A., Johnson, Gary L.
Publicado en NPJ Breast Cancer (2021)