Correlative Biomarker Analysis of Intrinsic Subtypes and Efficacy Across the MONALEESA Phase III Studies

by Prat, Aleix, Chaudhury, Anwesha, Solovieff, Nadia, Paré, Laia, Martinez, Débora, Chic, Nuria, Martínez-Sáez, Olga, Brasó-Maristany, Fara, Lteif, Agnes, Taran, Tetiana, Babbar, Naveen, Su, Fei
Published in J Clin Oncol (2021)

Frequency and spectrum of PIK3CA somatic mutations in breast cancer

by Martínez-Sáez, Olga, Chic, Nuria, Pascual, Tomás, Adamo, Barbara, Vidal, Maria, González-Farré, Blanca, Sanfeliu, Esther, Schettini, Francesco, Conte, Benedetta, Brasó-Maristany, Fara, Rodríguez, Adela, Martínez, Débora, Galván, Patricia, Rodríguez, Ana Belén, Martinez, Antonio, Muñoz, Montserrat, Prat, Aleix
Published in Breast Cancer Res (2020)

Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

by Patel, Nirmesh, Weekes, Daniel, Drosopoulos, Konstantinos, Gazinska, Patrycja, Noel, Elodie, Rashid, Mamun, Mirza, Hasan, Quist, Jelmar, Brasó-Maristany, Fara, Mathew, Sumi, Ferro, Riccardo, Pereira, Ana Mendes, Prince, Cynthia, Noor, Farzana, Francesch-Domenech, Erika, Marlow, Rebecca, de Rinaldis, Emanuele, Grigoriadis, Anita, Linardopoulos, Spiros, Marra, Pierfrancesco, Tutt, Andrew N. J.
Published in Nat Commun (2018)

Oestrogen receptor activity in hormone-dependent breast cancer during chemotherapy

by Chic, Nuria, Schettini, Francesco, Brasó-Maristany, Fara, Sanfeliu, Esther, Adamo, Barbara, Vidal, Maria, Martínez, Débora, Galván, Patricia, González-Farré, Blanca, Cortés, Javier, Gavilá, Joaquín, Saura, Cristina, Oliveira, Mafalda, Pernas, Sònia, Martínez-Sáez, Olga, Soberino, Jesús, Ciruelos, Eva, Carey, Lisa A., Muñoz, Montserrat, Perou, Charles M., Pascual, Tomás, Bellet, Meritxell, Prat, Aleix
Published in EBioMedicine (2021)

Circulating tumor DNA dynamics in advanced breast cancer treated with CDK4/6 inhibition and endocrine therapy

by Martínez-Sáez, Olga, Pascual, Tomás, Brasó-Maristany, Fara, Chic, Nuria, González-Farré, Blanca, Sanfeliu, Esther, Rodríguez, Adela, Martínez, Débora, Galván, Patricia, Rodríguez, Anna Belén, Schettini, Francesco, Conte, Benedetta, Vidal, Maria, Adamo, Barbara, Martínez, Antoni, Muñoz, Montserrat, Moreno, Reinaldo, Villagrasa, Patricia, Salvador, Fernando, Ciruelos, Eva M., Faull, Iris, Odegaard, Justin I., Prat, Aleix
Published in NPJ Breast Cancer (2021)

Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade

by Brasó-Maristany, Fara, Griguolo, Gaia, Pascual, Tomás, Paré, Laia, Nuciforo, Paolo, Llombart-Cussac, Antonio, Bermejo, Begoña, Oliveira, Mafalda, Morales, Serafín, Martínez, Noelia, Vidal, Maria, Adamo, Barbara, Martínez, Olga, Pernas, Sonia, López, Rafael, Muñoz, Montserrat, Chic, Núria, Galván, Patricia, Garau, Isabel, Manso, Luis, Alarcón, Jesús, Martínez, Eduardo, Gregorio, Sara, Gomis, Roger R., Villagrasa, Patricia, Cortés, Javier, Ciruelos, Eva, Prat, Aleix
Published in Nat Commun (2020)

ERBB2 mRNA Expression and Response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-Positive Breast Cancer

by Griguolo, Gaia, Brasó-Maristany, Fara, González-Farré, Blanca, Pascual, Tomás, Chic, Núria, Saurí, Tamara, Kates, Ronald, Gluz, Oleg, Martínez, Débora, Paré, Laia, Tsvetkova, Vassilena, Pesantez, David, Vidal, Maria, Adamo, Barbara, Muñoz, Montserrat, Galván, Patricia, Barberá, Laura, Cuatrecasas, Miriam, Christgen, Mathias, Kreipe, Hans, Monge-Escartín, Inés, Villagrasa, Patricia, Soy, Dolors, Giarratano, Tommaso, Dieci, Maria Vittoria, Conte, Pierfranco, Harbeck, Nadia, Guarneri, Valentina, Prat, Aleix
Published in Cancers (Basel) (2020)

Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer

by Schettini, Francesco, Chic, Nuria, Brasó-Maristany, Fara, Paré, Laia, Pascual, Tomás, Conte, Benedetta, Martínez-Sáez, Olga, Adamo, Barbara, Vidal, Maria, Barnadas, Esther, Fernández-Martinez, Aranzazu, González-Farre, Blanca, Sanfeliu, Esther, Cejalvo, Juan Miguel, Perrone, Giuseppe, Sabarese, Giovanna, Zalfa, Francesca, Peg, Vicente, Fasani, Roberta, Villagrasa, Patricia, Gavilá, Joaquín, Barrios, Carlos H., Lluch, Ana, Martín, Miguel, Locci, Mariavittoria, De Placido, Sabino, Prat, Aleix
Published in NPJ Breast Cancer (2021)

PIM1 kinase regulates cell death, tumor growth and chemotherapy response revealing a novel target in triple-negative breast cancer

by Brasó-Maristany, Fara, Filosto, Simone, Catchpole, Steven, Marlow, Rebecca, Quist, Jelmar, Francesch-Domenech, Erika, Plumb, Darren A., Zakka, Leila, Gazinska, Patrycja, Liccardi, Gianmaria, Meier, Pascal, Gris-Oliver, Albert, Cheang, Maggie Chon U, Perdrix-Rosell, Anna, Shafat, Manar, Noël, Elodie, Patel, Nirmesh, McEachern, Kristen, Scaltriti, Maurizio, Castel, Pau, Noor, Farzana, Buus, Richard, Mathew, Sumi, Watkins, Johnathan, Serra, Violeta, Marra, Pierfrancesco, Grigoriadis, Anita, Tutt, Andrew N.
Published in Nat Med (2016)

HER2-enriched subtype and pathological complete response in HER2-positive breast cancer: a systematic review and meta-analysis

by Schettini, Francesco, Pascual, Tomas, Conte, Benedetta, Chic, Nuria, Brasó-Maristany, Fara, Galván, Patricia, Martínez, Olga, Adamo, Barbara, Vidal, Maria, Muñoz, Montserrat, Fernández-Martinez, Aranzazu, Rognoni, Carla, Griguolo, Gaia, Guarneri, Valentina, Conte, Pier Franco, Locci, Mariavittoria, Brase, Jan C., Gonzalez-Farre, Blanca, Villagrasa, Patricia, De Placido, Sabino, Schiff, Rachel, Veeraraghavan, Jamunarani, Rimawi, Mothaffar F., Osborne, C. Kent, Pernas, Sonia, Perou, Charles M., Carey, Lisa A., Prat, Aleix
Published in Cancer Treat Rev (2020)

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

by Garcia-Recio, Susana, Thennavan, Aatish, East, Michael P., Parker, Joel S., Cejalvo, Juan M., Garay, Joseph P., Hollern, Daniel P., He, Xiaping, Mott, Kevin R., Galván, Patricia, Fan, Cheng, Selitsky, Sara R., Coffey, Alisha R., Marron, David, Brasó-Maristany, Fara, Burgués, Octavio, Albanell, Joan, Rojo, Federico, Lluch, Ana, de Dueñas, Eduardo Martinez, Rosen, Jeffery M., Johnson, Gary L., Carey, Lisa A., Prat, Aleix, Perou, Charles M.
Published in J Clin Invest (2020)

Genetic alterations in the PI3K/AKT pathway and baseline AKT activity define AKT inhibitor sensitivity in breast cancer patient-derived xenografts

by Gris-Oliver, Albert, Palafox, Marta, Monserrat, Laia, Brasó-Maristany, Fara, Òdena, Andreu, Sánchez-Guixé, Mònica, Ibrahim, Yasir H., Villacampa, Guillermo, Grueso, Judit, Parés, Mireia, Guzmán, Marta, Rodríguez, Olga, Bruna, Alejandra, Hirst, Caroline S., Barnicle, Alan, de Bruin, Elza, Reddy, Avinash, Schiavon, Gaia, Arribas, Joaquín, Mills, Gordon B., Caldas, Carlos, Dienstmann, Rodrigo, Prat, Aleix, Nuciforo, Paolo, Razavi, Pedram, Scaltriti, Maurizio, Turner, Nicholas C., Saura, Cristina, Davies, Barry R., Oliveira, Mafalda, Serra, Violeta
Published in Clin Cancer Res (2020)

HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Treated with Dual HER2 Blockade

by Prat, Aleix, Pascual, Tomás, De Angelis, Carmine, Gutierrez, Carolina, Llombart-Cussac, Antonio, Wang, Tao, Cortés, Javier, Rexer, Brent, Paré, Laia, Forero, Andres, Wolff, Antonio C, Morales, Serafín, Adamo, Barbara, Brasó-Maristany, Fara, Vidal, Maria, Veeraraghavan, Jamunarani, Krop, Ian, Galván, Patricia, Pavlick, Anne C, Bermejo, Begoña, Izquierdo, Miguel, Rodrik-Outmezguine, Vanessa, Reis-Filho, Jorge S, Hilsenbeck, Susan G, Oliveira, Mafalda, Dieci, Maria Vittoria, Griguolo, Gaia, Fasani, Roberta, Nuciforo, Paolo, Parker, Joel S, Conte, PierFranco, Schiff, Rachel, Guarneri, Valentina, Osborne, C Kent, Rimawi, Mothaffar F
Published in J Natl Cancer Inst (2019)

Development of a multi-parameter prognostic score to guide systemic therapy in early-stage HER2-positive breast cancer: a retrospective study with an external evaluation

by Prat, Aleix, Guarneri, Valentina, Paré, Laia, Griguolo, Gaia, Pascual, Tomás, Dieci, Maria Vittoria, Chic, Núria, González-Farré, Blanca, Frassoldati, Antonio, Sanfeliu, Esther, Cejalvo, Juan Miguel, Muñoz, Montserrat, Bisagni, Giancarlo, Brasó-Maristany, Fara, Urso, Loredana, Vidal, Maria, Brandes, Alba Ariela, Adamo, Barbara, Musolino, Antonino, Miglietta, Federica, Conte, Benedetta, Oliveira, Mafalda, Saura, Cristina, Pernas, Sònia, Alarcón, Jesús, Llombart-Cussac, Antonio, Cortés, Javier, Manso, Luis, López, Rafael, Ciruelos, Eva, Schettini, Francesco, Villagrasa, Patricia, Carey, Lisa A., Perou, Charles M., Piacentini, Federico, D’Amico, Roberto, Tagliafico, Enrico, Parker, Joel. S., Conte, Pierfranco
Published in Lancet Oncol (2020)