Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues

[Image: see text] ONC201 is a first-in-class imipridone molecule currently in clinical trials for the treatment of multiple cancers. Despite enormous clinical potential, the mechanism of action is controversial. To investigate the mechanism of ONC201 and identify compounds with improved potency, we...

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Publicado no:ACS Chem Biol
Main Authors: Graves, Paul R., Aponte-Collazo, Lucas J., Fennell, Emily M. J., Graves, Adam C., Hale, Andrew E., Dicheva, Nedyalka, Herring, Laura E., Gilbert, Thomas S. K., East, Michael P., McDonald, Ian M., Lockett, Matthew R., Ashamalla, Hani, Moorman, Nathaniel J., Karanewsky, Donald S., Iwanowicz, Edwin J., Holmuhamedov, Ekhson, Graves, Lee M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528275/
https://ncbi.nlm.nih.gov/pubmed/31021596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00222
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