Ureadepsipeptides as ClpP Activators

Acyldepsipeptides are a unique class of antibiotics that act via allosterically dysregulated activation of the bacterial caseinolytic protease (ClpP). The ability of ClpP activators to kill non-growing bacteria represents a new opportunity to combat deep-seated biofilm infections. However, the acyl...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Griffith, Elizabeth C., Zhao, Ying, Singh, Aman P., Conlon, Brian P., Tangallapally, Rajendra, Shadrick, William R., Liu, Jiuyu, Wallace, Miranda J., Yang, Lei, Elmore, John M., Li, Yong, Zheng, Zhong, Miller, Darcie J., Cheramie, Martin N., Lee, Robin B., LaFleur, Michael D., Lewis, Kim, Lee, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916429/
https://ncbi.nlm.nih.gov/pubmed/31588734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00245
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