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The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring

Mycobacterium tuberculosis (Mtb) contains two clpP genes, both of which are essential for viability. We expressed and purified Mtb ClpP1 and ClpP2 separately. Although each formed a tetradecameric structure and was processed, they lacked proteolytic activity. We could, however, reconstitute an activ...

詳細記述

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書誌詳細
主要な著者: Akopian, Tatos, Kandror, Olga, Raju, Ravikiran M, UnniKrishnan, Meera, Rubin, Eric J, Goldberg, Alfred L
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321190/
https://ncbi.nlm.nih.gov/pubmed/22286948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.5
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