The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring

Mycobacterium tuberculosis (Mtb) contains two clpP genes, both of which are essential for viability. We expressed and purified Mtb ClpP1 and ClpP2 separately. Although each formed a tetradecameric structure and was processed, they lacked proteolytic activity. We could, however, reconstitute an activ...

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Main Authors: Akopian, Tatos, Kandror, Olga, Raju, Ravikiran M, UnniKrishnan, Meera, Rubin, Eric J, Goldberg, Alfred L
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321190/
https://ncbi.nlm.nih.gov/pubmed/22286948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.5
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