Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease

The Clp protease complex in Mycobacterium tuberculosis is unusual in its composition, functional importance, and activation mechanism. While most bacterial species contain a single ClpP protein that is dispensable for normal growth, mycobacteria have two ClpPs, ClpP1 and ClpP2, which are essential f...

Full description

Saved in:
Bibliographic Details
Published in:Mol Microbiol
Main Authors: Famulla, Kirsten, Sass, Peter, Malik, Imran, Akopian, Tatos, Kandror, Olga, Alber, Marina, Hinzen, Berthold, Ruebsamen-Schaeff, Helga, Kalscheuer, Rainer, Goldberg, Alfred L., Brötz-Oesterhelt, Heike
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469208/
https://ncbi.nlm.nih.gov/pubmed/26919556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13362
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items