Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes

Acyldepsipeptide (ADEP) is an exploratory antibiotic with a novel mechanism of action. ClpP, the proteolytic core of the caseinolytic protease, is deregulated towards unrestrained proteolysis. Here, we report on the mechanism of ADEP resistance in Firmicutes. This bacterial phylum contains important...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Malik, Imran T., Pereira, Rebeca, Vielberg, Marie‐Theres, Mayer, Christian, Straetener, Jan, Thomy, Dhana, Famulla, Kirsten, Castro, Helena, Sass, Peter, Groll, Michael, Brötz‐Oesterhelt, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496096/
https://ncbi.nlm.nih.gov/pubmed/32181548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900787
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