Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes

Acyldepsipeptide (ADEP) is an exploratory antibiotic with a novel mechanism of action. ClpP, the proteolytic core of the caseinolytic protease, is deregulated towards unrestrained proteolysis. Here, we report on the mechanism of ADEP resistance in Firmicutes. This bacterial phylum contains important...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Chembiochem
Autors principals: Malik, Imran T., Pereira, Rebeca, Vielberg, Marie‐Theres, Mayer, Christian, Straetener, Jan, Thomy, Dhana, Famulla, Kirsten, Castro, Helena, Sass, Peter, Groll, Michael, Brötz‐Oesterhelt, Heike
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Full Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496096/
https://ncbi.nlm.nih.gov/pubmed/32181548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900787
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars