Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis, unlike most well studied prokaryotes, encode two ClpP homologs, ClpP1 and ClpP2, in a si...

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Detalhes bibliográficos
Main Authors: Raju, Ravikiran M., Unnikrishnan, Meera, Rubin, Daniel H. F., Krishnamoorthy, Vidhya, Kandror, Olga, Akopian, Tatos N., Goldberg, Alfred L., Rubin, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280978/
https://ncbi.nlm.nih.gov/pubmed/22359499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002511
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