In Vivo and In Vitro Effects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci

Antibiotics with novel bactericidal mechanisms of action are urgently needed. The antibiotic acyldepsipeptide 4 (ADEP4) activates the ClpP protease and causes cells to self-digest. The effects of ADEP4 and ClpP activation have not been characterized sufficiently for the enterococci, which are import...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Brown Gandt, Autumn, Griffith, Elizabeth C., Lister, Ida M., Billings, Lisa L., Han, Angel, Tangallapally, Rajendra, Zhao, Ying, Singh, Aman P., Lee, Richard E., LaFleur, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105829/
https://ncbi.nlm.nih.gov/pubmed/29784838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00424-18
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