Acyldepsipeptide Antibiotics Induces the Formation of a Structured Axial Channel in ClpP: a Model for the ClpX/ClpA Bound State of ClpP

In ClpXP and ClpAP complexes, ClpA and ClpX use the energy of ATP hydrolysis to unfold proteins and translocate them into the self-compartmentalized ClpP protease. ClpP requires the ATPases to degrade folded or unfolded substrates, but binding of acyldepsipeptide antibiotics (ADEPs) to ClpP bypasses...

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Autores principales: Li, Dominic Him Shun, Chung, Yu Seon, Gloyd, Melanie, Joseph, Ebenezer, Ghirlando, Rodolfo, Wright, Gerard D., Cheng, Yi-Qiang, Maurizi, Michael R., Guarné, Alba, Ortega, Joaquin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955292/
https://ncbi.nlm.nih.gov/pubmed/20851345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.07.008
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