Acyldepsipeptide Antibiotics Induces the Formation of a Structured Axial Channel in ClpP: a Model for the ClpX/ClpA Bound State of ClpP

In ClpXP and ClpAP complexes, ClpA and ClpX use the energy of ATP hydrolysis to unfold proteins and translocate them into the self-compartmentalized ClpP protease. ClpP requires the ATPases to degrade folded or unfolded substrates, but binding of acyldepsipeptide antibiotics (ADEPs) to ClpP bypasses...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Li, Dominic Him Shun, Chung, Yu Seon, Gloyd, Melanie, Joseph, Ebenezer, Ghirlando, Rodolfo, Wright, Gerard D., Cheng, Yi-Qiang, Maurizi, Michael R., Guarné, Alba, Ortega, Joaquin
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955292/
https://ncbi.nlm.nih.gov/pubmed/20851345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.07.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados