Loading...

Control of substrate gating and translocation into ClpP by channel residues and ClpX binding

ClpP is a self-compartmentalized protease, which has very limited degradation activity unless it associates with ClpX or ClpA to form the AAA+ ClpXP or ClpAP proteases. Here, we show that ClpX binding stimulates ClpP cleavage of peptides larger than a few amino acids and enhances ClpP active-site mo...

Full description

Saved in:
Bibliographic Details
Main Authors: Lee, Mary E., Baker, Tania A., Sauer, Robert T.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885556/
https://ncbi.nlm.nih.gov/pubmed/20416323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.027
Tags: Add Tag
No Tags, Be the first to tag this record!