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Control of substrate gating and translocation into ClpP by channel residues and ClpX binding
ClpP is a self-compartmentalized protease, which has very limited degradation activity unless it associates with ClpX or ClpA to form the AAA+ ClpXP or ClpAP proteases. Here, we show that ClpX binding stimulates ClpP cleavage of peptides larger than a few amino acids and enhances ClpP active-site mo...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2885556/ https://ncbi.nlm.nih.gov/pubmed/20416323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.027 |
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