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Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation

IGF‐motif loops project from the hexameric ring of ClpX and are required for docking with the self‐compartmentalized ClpP peptidase, which consists of heptameric rings stacked back‐to‐back. Here, we show that ATP or ATPγS support assembly by changing the conformation of the ClpX ring, bringing the I...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Amor, Alvaro J., Schmitz, Karl R., Baker, Tania A., Sauer, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423715/
https://ncbi.nlm.nih.gov/pubmed/30767302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3590
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