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Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation

IGF‐motif loops project from the hexameric ring of ClpX and are required for docking with the self‐compartmentalized ClpP peptidase, which consists of heptameric rings stacked back‐to‐back. Here, we show that ATP or ATPγS support assembly by changing the conformation of the ClpX ring, bringing the I...

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Vydáno v:Protein Sci
Hlavní autoři: Amor, Alvaro J., Schmitz, Karl R., Baker, Tania A., Sauer, Robert T.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423715/
https://ncbi.nlm.nih.gov/pubmed/30767302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3590
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