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Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX
The hexameric AAA+ ring of Escherichia. coli ClpX, an ATP-dependent protein unfolding and translocation machine, functions with the ClpP peptidase to degrade target substrates. For efficient function, ClpX subunits must switch between nucleotide-loadable (L) and nucleotide-unloadable (U) conformatio...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424054/ https://ncbi.nlm.nih.gov/pubmed/25866879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3012 |
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