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Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates

ClpX binds substrates bearing specific classes of peptide signals, denatures these proteins, and translocates them through a central pore into ClpP for degradation. ClpX with the V154F pore mutation is severely defective in binding substrates bearing C-motif 1 degradation signals and is also impaire...

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Hlavní autoři: Siddiqui, Samia M., Sauer, Robert T., Baker, Tania A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC359390/
https://ncbi.nlm.nih.gov/pubmed/15004005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1170304
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