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Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates

ClpX, an archetypal proteolytic AAA+ unfoldase, must engage the ssrA tags of appropriate substrates prior to ATP-dependent unfolding and translocation of the denatured polypeptide into ClpP for degradation. Here, specificity-transplant and disulfide-crosslinking experiments reveal that the ssrA tag...

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Bibliographic Details
Main Authors: Martin, Andreas, Baker, Tania A., Sauer, Robert T.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323458/
https://ncbi.nlm.nih.gov/pubmed/18313382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.02.002
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