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The ClpS adaptor mediates staged delivery of N-end-rule substrates to the AAA+ ClpAP protease
The ClpS adaptor delivers N-end-rule substrates to ClpAP, an energy-dependent AAA+ protease, for degradation. How ClpS binds specific N-end residues is known in atomic detail and clarified here, but the delivery mechanism is poorly understood. We show that substrate binding is enhanced when ClpS bin...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3168947/ https://ncbi.nlm.nih.gov/pubmed/21777811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.009 |
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