The ClpS adaptor mediates staged delivery of N-end-rule substrates to the AAA+ ClpAP protease

The ClpS adaptor delivers N-end-rule substrates to ClpAP, an energy-dependent AAA+ protease, for degradation. How ClpS binds specific N-end residues is known in atomic detail and clarified here, but the delivery mechanism is poorly understood. We show that substrate binding is enhanced when ClpS bin...

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Bibliographic Details
Main Authors: Román-Hernández, Giselle, Hou, Jennifer Y., Grant, Robert A., Sauer, Robert T., Baker, Tania A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168947/
https://ncbi.nlm.nih.gov/pubmed/21777811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.009
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